CCDC97 influences the immune microenvironment and biological functions in HCC.
- Author:
Lingling MO
1
;
Xinyue WU
2
;
Xiaohua PENG
1
;
Chuang CHEN
3
Author Information
1. Traditional Chinese Medicine Department of Guangxi Medical University Cancer Hospital, Nanning 530021, China.
2. Traditional Chinese Medicine Department of The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
3. Traditional Chinese Medicine Department of Guangxi Medical University Cancer Hospital, Nanning 530021, China. *Corresponding author, E-mail: H1993005@sr.gxmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Carcinoma, Hepatocellular/metabolism*;
Liver Neoplasms/metabolism*;
Tumor Microenvironment/genetics*;
Cell Movement/genetics*;
Cell Proliferation;
Prognosis;
Cell Line, Tumor;
Gene Expression Regulation, Neoplastic;
Biomarkers, Tumor/genetics*;
Male
- From:
Chinese Journal of Cellular and Molecular Immunology
2025;41(1):23-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical and immunological significance of CCDC97 in hepatocellular carcinoma (HCC). Methods Clinical data and RNA sequencing results from HCC patients were retrieved from TCGA and ICGC databases. Bioinformatics analysis and in vitro experiments were performed to investigate the role of CCDC97 in HCC. Results The expression level of CCDC97 was elevated in HCC patients and HCC cells, closely associated with pathological features and prognosis. CCDC97 was identified as a novel prognostic biomarker. It is linked to the spliceosome pathway, which is significantly active in tumors and potentially promotes carcinogenesis. CCDC97 is also highly expressed in various immune cells and is associated with microenvironment. Furthermore, knocking down CCDC97 in vitro suppressed cell migration, invasion, and proliferation. Conclusion CCDC97 plays a critical role in HCC progression and the immune microenvironment, making it a potential target for prognosis and therapeutic intervention.
