Research progress on the role of exosomes in respiratory diseases.
- Author:
Yiting GAO
1
;
Xinyang BU
1
;
Manxin DU
2
;
Jiayun LIU
3
,
4
;
Xiang ZHANG
4
,
5
Author Information
1. Department of Clinical Laboratory, Xijing Hospital, Regiment Four of Cadets, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China.
2. Department of Clinical Laboratory, Xijing Hospital, Regiment One of Cadets, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China.
3. Department of Clinical Laboratory, Xijing Hospital, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail:jiayun@
4. com.
5. Department of Clinical Laboratory, Xijing Hospital, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail: cicixiangz@
- Publication Type:English Abstract
- MeSH:
Exosomes/immunology*;
Humans;
Respiratory Tract Diseases/therapy*;
Animals;
Biomarkers
- From:
Chinese Journal of Cellular and Molecular Immunology
2024;40(11):1044-1049
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are extracellular vesicles that can be secreted by various cells and widely exist in body fluids such as blood and urine. During the progression of respiratory tract diseases, exosomes derived from epithelial and immune cells can secrete substances such as RNA and proteins, disrupting the respiratory defense system and inducing or exacerbating the disease. Exosomes derived from circulating and lung tissues can be used as potential diagnostic markers for respiratory diseases, which greatly improves the diagnostic sensitivity and specificity for respiratory diseases such as tumors and infections. The treatment of respiratory diseases is also closely related to exosomes. The low immunogenicity and high compatibility of exosomes make them effective tools for delivering molecules and drugs for treatment.
