Research progress on the effect of tumor-associated macrophages on breast cancer and its targeted therapy.
- Author:
Juan ZHAO
1
;
Junjun CHEN
2
;
Yangyun ZHOU
2
;
Lingyan XU
2
;
Xiaohe WANG
2
;
Yonglong HAN
3
,
4
Author Information
1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306; Department of Pharmacy, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
2. Department of Pharmacy, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
3. Department of Pharmacy, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China. *Corresponding author, E-mail: yonglongh@
4. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Breast Neoplasms/pathology*;
Female;
Tumor-Associated Macrophages/drug effects*;
Tumor Microenvironment/drug effects*;
Animals;
Molecular Targeted Therapy/methods*
- From:
Chinese Journal of Cellular and Molecular Immunology
2024;40(11):1035-1043
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages (TAMs), a crucial component of the tumor microenvironment (TME), are closely associated to the growth, invasion, metastasis, and prognosis of breast cancer. Targeting TAMs is considered to be a potential new strategy for improving the therapeutic efficacy of breast cancer. TAMs interact with breast cancer cells and influence the development and progression of various breast cancer subtypes through multiple pathways, including the secretion of proteins, cytokines, chemokines, and exosomes. Anti-breast cancer drugs targeting TAMs and emerging therapies are continually being discovered. This article explores the effects and mechanisms of TAMs in different breast cancer subtypes, examines the anti-breast cancer effects of herbal extracts and their active ingredients targeting TAMs, and introduces new technologies such as nano-agents, gene therapy, and immunocellular therapy that target TAMs. These therapeutic strategies targeting TAMs may be critical in improving the therapeutic efficacy and prognosis of breast cancer patients.
