Research advance of interleukin 24.
- Author:
Mengyang ZHU
1
;
Wen CHEN
2
;
Tao ZHANG
3
;
Li XIAO
4
,
5
Author Information
1. Institute of Respiratory and Critical Care Medicine, Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory, the 8th Medical Center of Chinese PLA General Hospital, Beijing 100091; Department of Immunology, School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
2. Department of Pathology, the 8th Medical Center of Chinese PLA General Hospital, Beijing 100091, China.
3. Department of Immunology, School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
4. Institute of Respiratory and Critical Care Medicine, Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory, the 8th Medical Center of Chinese PLA General Hospital, Beijing 100091, China. *Corresponding author, E-mail: xiaolilab309@
5. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Animals;
Interleukins/physiology*;
Signal Transduction;
Endoplasmic Reticulum Stress;
p38 Mitogen-Activated Protein Kinases/metabolism*;
Neoplasms/metabolism*;
Autoimmune Diseases/metabolism*;
Inflammation/immunology*;
STAT Transcription Factors/metabolism*;
Janus Kinases/metabolism*
- From:
Chinese Journal of Cellular and Molecular Immunology
2024;40(11):1024-1028
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin 24 (IL-24) is a member of the IL-10 cytokine family and is primarily synthesized by lymphocytes and activated monocytes. IL-24 exerts its immunological functions by interacting with membrane receptors or intracellular proteins, leading to the activation of Janus protein tyrosine kinase/signal transducer and activator of transcription (JAK/STAT), p38 mitogen-activated protein kinase (p38 MAPK), and endoplasmic reticulum stress pathways in target cells. This versatile cytokine has specific abilities to inhibit tumor proliferation and invasion, expedite wound healing, and contribute to cardiovascular protection. IL-24 is involved in the pathogenesis of various autoimmune and inflammatory disorders, presenting itself as a prospective therapeutic target for the treatment of such conditions. This article primarily delves into the role and mechanisms of IL-24 in physiological processes, aiming to provide novel insights and avenues for disease treatment.
