Research progresses of Qa-1 restricted CD8+ regulatory T cells in the pathogenesis of infectious diseases.
- Author:
Xiaoyue XU
1
;
Manling XUE
1
;
Jiajia ZUO
1
;
Kang TANG
2
;
Yusi ZHANG
2
;
Chunmei ZHANG
2
;
Ran ZHUANG
2
;
Yun ZHANG
2
;
Boquan JIN
2
;
Yuhong LYU
3
,
4
;
Ying MA
5
Author Information
1. Medical school of Yan'an university, Yan'an 716000; Department of immunology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China.
2. Department of immunology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China.
3. Medical school of Yan'an university, Yan'an 716000, China. *Corresponding authors, E-mail: yuhonglyu@
4. com.
5. Department of immunology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail: mayingying@fmmu.edu.cn.
- Publication Type:English Abstract
- MeSH:
Humans;
Animals;
T-Lymphocytes, Regulatory/immunology*;
Histocompatibility Antigens Class I/immunology*;
CD8-Positive T-Lymphocytes/immunology*;
Communicable Diseases/immunology*
- From:
Chinese Journal of Cellular and Molecular Immunology
2024;40(11):1018-1023
- CountryChina
- Language:Chinese
-
Abstract:
The Qa-1 in mice is homologous to human leukocyte antigen E(HLA-E), and both of them belong to the non-classical major histocompatibility complex I b(MHC-I b) molecules. Qa-1 is capable of presenting self or exogenous antigen peptides to interact with two distinct receptors, namely T cell receptor (TCR) and natural killer cell group 2 member A (or C) (NKG2A/C), thus playing an important role in immune response and regulation. Qa-1-restricted regulatory CD8+ T cell (CD8+ Treg) is one of the most studied CD8+ Treg subgroups, which can maintain immune homeostasis and autoimmune tolerance by exerting immunosuppressive effects. Consequently, Qa-1-restricted CD8+Treg cells are closely associated with the occurrence and development of various clinical diseases, such as tumors, infections, autoimmune diseases, and transplant rejections. This paper provides a comprehensive review of the phenotypic characteristics, functional effects, regulatory mechanisms of Qa-1-restricted CD8+ Treg cells, as well as the latest research progresses of Qa-1-restricted CD8+ Treg cells involved in the pathogenesis of infectious diseases.
