Research progress on the regulation of Hippo -YAP signaling pathway in osteoarthritis.
10.12200/j.issn.1003-0034.20230522
- Author:
Xi-Yao TAI
1
;
De-Cai HOU
2
;
Jiang ZHANG
1
;
Xiao-Lei DENG
2
Author Information
1. Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China.
2. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, Liaoning, China; Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang 110000, Liaoning, China.
- Publication Type:English Abstract
- Keywords:
Apoptosis;
Differentiation;
Hippo-YAP pathway;
Mesenchymal stem cells;
Osteoarthritis
- MeSH:
Osteoarthritis/metabolism*;
Humans;
Signal Transduction;
Protein Serine-Threonine Kinases/physiology*;
Hippo Signaling Pathway;
YAP-Signaling Proteins;
Adaptor Proteins, Signal Transducing/physiology*;
Animals;
Transcription Factors;
Chondrocytes/cytology*;
Cell Cycle Proteins
- From:
China Journal of Orthopaedics and Traumatology
2025;38(7):759-764
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (OA) is the most common degenerative joint disease. Its pathological process is related to inflammatory response, chondrocyte apoptosis, and cartilage degeneration. Hippo-yes-associate protein(YAP) signaling pathway plays an important role in mediating organ size and tissue homeostasis. In recent years, the key effector protein YAP in the Hippo-YAP pathway has become a research hotspot in osteoarthritis. This article introduces the activation process of Hippo-YAP signaling pathway and the biological role of YAP. It reviews the progress of YAP in regulating osteoarthritis by influencing the proliferation and differentiation of mesenchymal stem cells and the proliferation, differentiation, and apoptosis of articular chondrocytes. It analyzed the problems encountered in YAP research in OA, introduces the research potential of YAP in other orthopedic diseases, and provides new ideas for subsequent research in Osteoarthritis.
