Mechanism of traditional Chinese medicine monomers on regulating bone marrow mesenchymal stem cells to promote tendon-bone healing.
10.12200/j.issn.1003-0034.20240899
- Author:
Xiang-Zhe MENG
1
;
Guan-Ming TIAN
2
;
Lei HAN
3
;
Tuo WANG
3
Author Information
1. Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 311201, Zhejiang, China.
2. Xiaoshan Yongxin Hospital, Hangzhou 311223, Zhejiang, China.
3. Department of Orthopaedics, Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou 311201, Zhejiang, China.
- Publication Type:English Abstract
- Keywords:
Bone mesenchymal stem cells;
Review;
Tendon-bone healing;
Traditional Chinese medicine;
Traditional Chinese medicine monomer
- MeSH:
Mesenchymal Stem Cells/cytology*;
Humans;
Animals;
Bone Marrow Cells/cytology*;
Bone and Bones/drug effects*;
Wound Healing/drug effects*;
Medicine, Chinese Traditional;
Tendons/drug effects*;
Drugs, Chinese Herbal/pharmacology*;
Signal Transduction/drug effects*;
Cell Differentiation/drug effects*
- From:
China Journal of Orthopaedics and Traumatology
2025;38(6):645-650
- CountryChina
- Language:Chinese
-
Abstract:
The healing of the tendon-bone interface is a complex dynamic process involving the interaction of multiple cellular and molecular signaling pathways. Bone mesenchymal stem cells (BMSCs) have the potential to differentiate into various types of cells, including osteoblasts, chondrocytes and adipocytes, etc., and have the potential to regenerate damaged tissues. They are potential seed cells for promoting tendon-bone healing. How to precisely regulate the proliferation and differentiation of BMSCs to accelerate the process of tendon-bone healing is a current research hotspot. Monomers of traditional Chinese medicine can promote tendon-bone healing by regulating signaling pathways such as Wnt/β-catenin and BMP/Smad to induce osteogenic and chondrogenic differentiation of BMSCs. This article reviews from several aspects such as the regulatory role of related signaling pathways on tendine-bone healing, traditional Chinese medicine monomers and their mechanism of regulating BMSCs to promote tendine-bone healing in order to providing new ideas for promoting tendine-bone healing.
