Oxidative stress and chondrocytes in osteoarthritis:advances in mechanisms of action and therapeutic strategies.
10.12200/j.issn.1003-0034.20240396
- Author:
Ye-Long TAO
1
;
Jian-Bo FAN
2
Author Information
1. Department of Orthopaedics, the 2nd Hospital Affiliated to Nantong University, Nantong First People's Hospital, Nantong 226014, Jiangsu, China.
2. Department of Orthopaedics, the 2nd Hospital Affiliated to Nantong University, Nantong First People's Hospital, Nantong 226014, Jiangsu, China; Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong 226000, Jiangsu, China.
- Publication Type:English Abstract
- Keywords:
Cartilage;
Chondrocytes;
Osteoarthritis;
Oxidative stress;
Reactive oxygen species
- MeSH:
Humans;
Oxidative Stress;
Osteoarthritis/pathology*;
Chondrocytes/pathology*;
Animals;
Reactive Oxygen Species/metabolism*
- From:
China Journal of Orthopaedics and Traumatology
2025;38(4):434-440
- CountryChina
- Language:Chinese
-
Abstract:
With the deepening understanding of the pathogenesis of osteoarthritis (OA), therapeutic strategies targeting oxidative stress in chondrocytes have gradually become a research hotspot. This article summarizes the important role of oxidative stress in the development of OA, pointing out that it is closely related to chondrocyte senescence, inflammatory cascade reaction, and cartilage matrix degradation. Given the central role of oxidative stress in the pathological process of OA, inhibiting oxidative stress and the generation of reactive oxygen species (ROS) is considered the key to alleviating chondrocyte damage and senescence, and preventing the progression of OA. Although some progress has been made in current OA research, there are still many challenges, such as the in-depth understanding of the etiology of OA and the limited selection of therapeutic drugs. Future research will focus on a more comprehensive understanding of the mechanism of oxidative stress in OA, exploring new biomarkers and therapeutic targets, and developing new drugs or treatment methods targeting oxidative stress pathways. These efforts are expected to bring more effective treatment options to OA patients, thereby improving their quality of life and prognosis.
