Research progress on polymorphism of vitamin D and its receptor gene and susceptibility to bone tuberculosis.
10.12200/j.issn.1003-0034.20240312
- Author:
Xin-Feng LIU
1
;
Yan-Jun ZHANG
2
;
Jun-Jie LI
1
;
Jun YANG
1
;
Hong-Jing TIAN
1
Author Information
1. Gansu University of Chinese Mdicine, Lanzhou 730000, Gansu, China.
2. Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu, China.
- Publication Type:English Abstract
- Keywords:
Bone tuberculosis;
Review literature;
Susceptibility;
Vitamin D;
Vitamin D receptor
- MeSH:
Humans;
Receptors, Calcitriol/genetics*;
Genetic Predisposition to Disease;
Polymorphism, Genetic;
Vitamin D/metabolism*;
Tuberculosis, Osteoarticular/metabolism*
- From:
China Journal of Orthopaedics and Traumatology
2025;38(2):211-216
- CountryChina
- Language:Chinese
-
Abstract:
Bone tuberculosis is one of the main lesions of extrapulmonary tuberculosis, and the affected site shows local pain and limited movement, and the severe patients face a higher risk of teratogenicity and disability. Especially in the context of the increasing spread of multidrug-resistant tuberculosis, it is particularly urgent to seek innovative treatment options. In recent years, vitamin D plays an important role in the prevention and treatment of bone tuberculosis, and the mechanism of action has been continuously explored. At the same time, vitamin D receptor gene polymorphism has also been found to be closely related to the susceptibility and risk of bone tuberculosis. This article reviewed the relationship between vitamin D and its receptor gene polymorphisms and the susceptibility to bone tuberculosis. It was found that vitamin D deficiency increased the susceptibility to bone tuberculosis in both adults and children, and multiple genotypes of vitamin D receptor had an effect on the susceptibility to bone tuberculosis, especially FokⅠ genotype. It may also be one of the reasons for the increase in the number of bone tuberculosis. Through the study of the relationship between vitamin D and its receptor gene polymorphism and the susceptibility to bone tuberculosis, some factors inducing bone tuberculosis can be avoided, and related new drugs can be more targeted, such as vitamin D supplements, gene receptor related antagonists, etc. To provide more systematic and targeted strategies for the prevention and treatment of bone tuberculosis.
