Research progress on the repair of tendon injuries with Tissue Engineering Technology.
10.12200/j.issn.1003-0034.20240545
- Author:
Yan-Jun WANG
1
;
Ling-Tong KONG
2
;
Shuo-Gui XU
2
Author Information
1. Department of Emergency, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
2. Department of Orthopaedics, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.
- Publication Type:English Abstract
- Keywords:
Biosignals;
Injury and repair;
Seed cells;
Tendon;
Tissue engineering scaffold
- MeSH:
Tissue Engineering/methods*;
Tendon Injuries/surgery*;
Humans;
Tissue Scaffolds;
Animals;
Tendons;
Wound Healing
- From:
China Journal of Orthopaedics and Traumatology
2024;37(11):1126-1131
- CountryChina
- Language:Chinese
-
Abstract:
Tendon injuries are frequently encountered in clinical practice, and traditional repair methods rarely achieve complete restoration of the tendon's original structure and functionality. The challenges of accelerating and optimizing the healing of injured tendons, enhancing the strength of the regenerated tendon, and preventing adhesion remain significant in clinical settings. Tendon tissue engineering, which combines material science, cell biology, and molecular biology, involves the synergistic application of multiple factors to create functional constructs and has become an emerging technique with promise for repair. The maximization of the regenerative potential of these elements is a critical research question. Future research should concentrate on discovering the optimal combinations of cells, biosignals, and scaffolds to produce tissue that emulates the characteristics of an undamaged, natural tendon. This review will cover various aspects, including the fabrication of tendon tissue scaffolds, the selection of seed cells, strategies for the modulation of healing-related biosignals, and provide a summary with prospective insights, aiming to enhance the comprehension of tissue engineering techniques in tendon injury repair and to inspire innovative applications in this domain.
