Attributable disease burden of low bone mineral density related fractures in people over 50 years old from 1990 to 2023 in China.
10.7507/1002-1892.202507110
- Author:
Zepeng LAI
1
;
Yunxiao WU
1
;
Juxi JIANG
1
;
Xiang SHU
1
;
Ziqian ZENG
1
;
Weizhong CHEN
1
Author Information
1. School of Public Health, Chengdu Medical College, Chengdu Sichuan, 610500, P. R. China.
- Publication Type:Journal Article
- Keywords:
Fracture;
disease burden;
fall;
fragility fracture;
low bone mineral density;
the elderly;
trend analysis
- MeSH:
Humans;
China/epidemiology*;
Middle Aged;
Female;
Male;
Bone Density;
Aged;
Incidence;
Osteoporotic Fractures/epidemiology*;
Aged, 80 and over;
Accidental Falls/statistics & numerical data*;
Cost of Illness;
Global Burden of Disease;
Osteoporosis/complications*;
Disability-Adjusted Life Years;
Fractures, Bone/epidemiology*
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2025;39(11):1363-1370
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To estimate the population attributable disease burden (PAD) of low bone mineral density (LBMD) related fractures (fragility fractures) among Chinese people over 50 years old from 1990 to 2023, using data from the Global Burden of Disease Study 2023 (GBD 2023), and to provide evidence for prevention strategies and health resource allocation.
METHODS: Based on the GBD 2023, the LBMD summary exposure values (SEV), fracture incidence, years lived with disability (YLDs), and LBMD-related falls YLDs of Chinese people over 50 years old from 1990 to 2023 were extracted. PAD was calculated with population attributable fraction (PAF), and an entropy-weight method was applied to evaluate the contribution of individual fracture sites. Temporal trends and sex differences were examined with Joinpoint regression.
RESULTS: From 1990 to 2023, the age-standardized SEV of LBMD in people over 50 years old showed an overall decline [average annual percent change (AAPC)=-0.564%]. Age-standardized fracture incidence, fracture YLDs rate, and LBMD-related falls YLDs rate all exhibited W-shaped upward trends (AAPC=1.045%, 0.296%, and 0.724%, respectively). PAF-based estimates indicated that LBMD-attributable fracture incidence likewise increased in a "W-shaped" manner (AAPC=0.558%), whereas the corresponding YLDs rate showed an overall W-shaped decline (AAPC=-0.193%). In international comparison, China and the global average displayed broadly concordant directions of change, with greater volatility in China and a progressive narrowing of the gap after 2015. Regarding sex differences, fracture YLDs rates were consistently higher in the males, whereas the other burden indicators were higher in the females; the temporal patterns were similar in both sexes. Entropy weight method identified hip fractures as contributing most to incidence (weight 0.133), and pelvic fractures as the largest contributor to YLDs rate (weight 0.115).
CONCLUSION:Since 1990, the LBMD attributable fracture burden in China's older population has risen, with female and hip or pelvic fractures bearing the heaviest load. Strengthened osteoporosis screening, improved insurance coverage, and targeted health education are urgently needed to curb further increases in disease burden.
