Research progress in auxiliary components of nerve conduit for treating peripheral nerve injuries.
10.7507/1002-1892.202505083
- Author:
Chaocao NONG
1
;
Haodong LIN
1
Author Information
1. Trauma Center, Affiliated First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, P. R. China.
- Publication Type:English Abstract
- Keywords:
Nerve conduit;
guided tissue regeneration;
nerve regeneration;
peripheral nerve injury
- MeSH:
Peripheral Nerve Injuries/surgery*;
Nerve Regeneration;
Humans;
Tissue Scaffolds;
Animals;
Guided Tissue Regeneration/methods*;
Tissue Engineering/methods*;
Biocompatible Materials;
Peripheral Nerves;
Drug Delivery Systems
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2025;39(8):1061-1067
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review recent research progress in the use of auxiliary components of nerve conduits for the treatment of peripheral nerve injuries.
METHODS:An extensive review of recent domestic and international literature was conducted to evaluate the role of auxiliary components in nerve conduits for peripheral nerve repair, with a focus on their effects and underlying mechanisms.
RESULTS:By incorporating auxiliary components such as bioactive molecules, therapeutic cells, and their derivatives, nerve conduits can create a more biomimetic regenerative microenvironment. This is achieved by providing neurotrophic support, modulating the immune microenvironment, improving blood and oxygen supply, and offering directional guidance for nerve regeneration. Consequently, the nerve conduit is transformed from a simple physical scaffold into an active, bio-functional repair system, which enhances the effectiveness for PNI.
CONCLUSION:While nerve conduits augmented with auxiliary components demonstrate improved effectiveness, further advancements are required in drug delivery systems and the integration of cellular components. Moreover, most current studies are based on animal or in vitro experiments. Randomized controlled clinical trials are necessary to validate their clinical effectiveness.
