Advances in mechanotransduction signaling pathways in distraction osteogenesis.
10.7507/1002-1892.202504004
- Author:
Jinghong YANG
1
;
Lujun JIANG
1
;
Zi WANG
1
;
Zhong LI
1
;
Yanshi LIU
1
Author Information
1. Orthopedics and Sports Medicine Center, Affiliated Hospital, Southwest Medical University, Luzhou Sichuan, 646000, P. R. China.
- Publication Type:English Abstract
- Keywords:
Mechanotransduction signaling pathway;
distraction osteogenesis;
mechanical stress;
mechanosensitive ion channel
- MeSH:
Mechanotransduction, Cellular/physiology*;
Osteogenesis, Distraction/methods*;
Humans;
Signal Transduction;
Bone Regeneration;
Animals;
Osteoblasts/metabolism*;
Osteogenesis;
Transforming Growth Factor beta/metabolism*;
Ion Channels/metabolism*;
Integrins/metabolism*;
beta Catenin/metabolism*;
Bone Morphogenetic Proteins/metabolism*;
Smad Proteins/metabolism*
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2025;39(7):912-918
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review the role and research progress of mechanotransduction signaling pathway in distraction osteogenesis, so as to provide theoretical basis and reference for clinical treatment.
METHODS:The role and research progress of mechanotransduction signaling pathway in distraction osteogenesis were summarized by extensive review of relevant literature at home and abroad.
RESULTS:The mechanotransduction signaling pathway plays a central role of "sensation-transformation-execution" in distraction osteogenesis, and activates a series of molecular mechanisms to promote the regeneration and remodeling of bone tissue by integrating external mechanical signals. Mechanical stimuli are converted into mechanotransduction signals through the perception of integrins, Piezo1 ion channels and bone cell networks. Activate downstream molecules are transduce through signal pathways such as Wnt/β-catenin, transforming growth factor β/bone morphogenetic protein-Smad, mitogen-activated protein kinase, protein kinase Hippo-Yes-associated protein/transcriptional coactivator with PDZ-binding motif, and phosphatidylinositol 3-kinase/ protein kinase B, so as to achieve the effects of promoting osteoblasts proliferation, accelerating endochondral ossification, regulating bone resorption and the like, thereby promoting the regeneration of new bone in the distraction area. The study of mechanotransduction signaling pathways in distraction osteogenesis is expected to optimize the mechanical parameters of distraction osteogenesis and provide targeted intervention strategies for accelerating new bone regeneration and mineralization in the distraction zone. However, the specific mechanism of mechanotransduction signaling pathway in distraction osteogenesis remains to be further elucidated, and artificial intelligence and multi-omics analysis may be the future development direction of mechanotransduction signaling pathway.
CONCLUSION:In distraction osteogenesis, mechanotransduction signal transduction is the core mechanism of bone regeneration in the distraction zone, which regulates cell behavior and tissue regeneration by converting mechanical stimulation into biochemical signals.
