Research progress in three-dimensional-printed bone scaffolds combined with vascularized tissue flaps for segmental bone defect reconstruction.
10.7507/1002-1892.202503081
- Author:
Qida DUAN
1
;
Hongyun SHAO
1
;
Ning LUO
1
;
Fuyang WANG
1
;
Liangliang CHENG
1
;
Jiawei YING
1
;
Dewei ZHAO
1
Author Information
1. Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian Liaoning, 116001, P. R. China.
- Publication Type:English Abstract
- Keywords:
Segmental bone defect;
artificial bone scaffold;
biomaterial;
three-dimensional printing;
vascularized tissue flap graft
- MeSH:
Printing, Three-Dimensional;
Tissue Scaffolds;
Humans;
Surgical Flaps/blood supply*;
Tissue Engineering/methods*;
Plastic Surgery Procedures/methods*;
Bone and Bones/surgery*;
Biocompatible Materials;
Bone Regeneration;
Bone Transplantation/methods*;
Bone Substitutes;
Osteogenesis
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2025;39(5):639-646
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review and summarize the research progress on repairing segmental bone defects using three-dimensional (3D)-printed bone scaffolds combined with vascularized tissue flaps in recent years.
METHODS:Relevant literature was reviewed to summarize the application of 3D printing technology in artificial bone scaffolds made from different biomaterials, as well as methods for repairing segmental bone defects by combining these scaffolds with various vascularized tissue flaps.
RESULTS:The combination of 3D-printed artificial bone scaffolds with different vascularized tissue flaps has provided new strategies for repairing segmental bone defects. 3D-printed artificial bone scaffolds include 3D-printed polymer scaffolds, bio-ceramic scaffolds, and metal scaffolds. When these scaffolds of different materials are combined with vascularized tissue flaps ( e.g., omental flaps, fascial flaps, periosteal flaps, muscular flaps, and bone flaps), they provide blood supply to the inorganic artificial bone scaffolds. After implantation into the defect site, the scaffolds not only achieve structural filling and mechanical support for the bone defect area, but also promote osteogenesis and vascular regeneration. Additionally, the mechanical properties, porous structure, and biocompatibility of the 3D-printed scaffold materials are key factors influencing their osteogenic efficiency. Furthermore, loading the scaffolds with active components such as osteogenic cells and growth factors can synergistically enhance bone defect healing and vascularization processes.
CONCLUSION:The repair of segmental bone defects using 3D-printed artificial bone scaffolds combined with vascularized tissue flap transplantation integrates material science technologies with surgical therapeutic approaches, which will significantly improve the clinical treatment outcomes of segmental bone defect repair.
