Research progress on strontium modified β-tricalcium phosphate composite biomaterials with immune regulatory properties.
10.7507/1002-1892.202502063
- Author:
Huanxi LI
1
;
Xingyu SHAN
2
;
Hongda WANG
2
;
Zhimin TIAN
2
;
Chunnuo HE
2
;
Haoqiang ZHANG
1
Author Information
1. Department of Joint Surgery, the 940th Hospital of Chinese PLA Joint Logistics Support Force, Lanzhou Gansu, 730000, P. R. China.
2. The First Clinical College of Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou Gansu, 730000, P. R. China.
- Publication Type:English Abstract
- Keywords:
Bone repair;
immune regulation;
strontium;
β-tricalcium phosphate
- MeSH:
Calcium Phosphates/pharmacology*;
Strontium/pharmacology*;
Biocompatible Materials/pharmacology*;
Humans;
Osteogenesis/drug effects*;
Tissue Engineering/methods*;
Bone Substitutes/pharmacology*;
Bone Regeneration/drug effects*;
Animals;
Tissue Scaffolds/chemistry*;
Neovascularization, Physiologic/drug effects*;
Macrophages/immunology*
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2025;39(4):511-517
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review the research progress of strontium (Sr) modified β-tricalcium phosphate composite biomaterials (SrTCP) promoting osteogenesis through immune regulation, and provides reference and theoretical support for the further development and research of SrTCP bone repair materials in bone tissue engineering in the future.
METHODS:The literature about SrTCP promoting osteogenesis through immune regulation at home and abroad in recent years was extensively reviewed, and the preparation methods, immune mechanism and application of promoting osteogenesis were summarized and analyzed.
RESULTS:The preparation methods of SrTCP include solid-state reaction sintering method, solution combustion quenching method, direct doping method, ion substitution method, etc. SrTCP has immune regulatory effects, which can play an immune regulatory role in inducing macrophage polarization, inducing angiogenesis and anti oxidative stress to promote osteogenesis.
CONCLUSION:At present, studies have shown that SrTCP can promote bone defect repair through immune regulation. Subsequent studies can start from the control of the optimal repair concentration and release rate of Sr, and further clarify the specific mechanism of SrTCP in promoting angiogenesis and anti oxidative stress, which is helpful to develop new materials for bone defect repair.
