Application and progress of intelligent responsive hydrogels in articular cartilage injury repair.
10.7507/1002-1892.202411015
- Author:
Qingyu XU
1
;
Baojian ZHANG
1
;
Hongri LI
1
;
Chengri LIU
1
;
Shuhao BI
1
;
Zhixiang YANG
1
;
Yanqun LIU
1
Author Information
1. Orthopedic Diagnosis and Treatment Center, Yanbian University Hospital (Yanbian Hospital), Yanji Jilin, 133000, P. R. China.
- Publication Type:English Abstract
- Keywords:
Intelligent responsive hydrogel;
cartilage injury;
repair;
response principle
- MeSH:
Hydrogels/therapeutic use*;
Cartilage, Articular/injuries*;
Tissue Engineering/methods*;
Humans;
Animals;
Chondrocytes/cytology*;
Biocompatible Materials/chemistry*;
Tissue Scaffolds/chemistry*
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2025;39(2):250-256
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review clinical application and research progress of different types of intelligent responsive hydrogels in repairing articular cartilage injury.
METHODS:The animal experiments and clinical studies of different types of intelligent responsive hydrogels for repairing articular cartilage injury were summarized by reviewing relevant literature at home and abroad.
RESULTS:The intrinsic regenerative capacity of articular cartilage following injury is limited. Intelligent responsive hydrogels, including those that are temperature-sensitive, light-sensitive, enzyme-responsive, pH-sensitive, and other stimuli-responsive hydrogels, can undergo phase transitions in response to specific stimuli, thereby achieving optimal functionality. These hydrogels can fill the injured cartilage area, promote the proliferation and differentiation of chondrocytes, and expedite the repair of the damaged site. With advancements in cartilage tissue engineering materials research, intelligent responsive hydrogels offer a novel approach and promising potential for the treatment of cartilage injuries.
CONCLUSION:Intelligent responsive hydrogel is a kind of flexible, controllable, efficient, and stable polymer, which has similar structure and functional properties to articular cartilage, and has become one of the important biomaterials for cartilage repair. However, there is still a lack of unified treatment standards and simple and efficient preparation technology.
