Research progress of bioactive scaffolds in repair and regeneration of osteoporotic bone defects.
10.7507/1002-1892.202410018
- Author:
Yuangang WU
1
;
Kaibo SUN
1
;
Yi ZENG
1
;
Bin SHEN
1
Author Information
1. Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
- Publication Type:English Abstract
- Keywords:
Osteoporosis;
bioactive scaffold;
biotechnology;
bone defect;
osteogenic differentiation;
regenerative medicine
- MeSH:
Humans;
Tissue Scaffolds/chemistry*;
Bone Regeneration;
Osteoporosis/therapy*;
Tissue Engineering/methods*;
Biocompatible Materials/chemistry*;
Printing, Three-Dimensional;
Calcium Phosphates/chemistry*;
Osteogenesis;
Ceramics;
Cell Differentiation;
Hydrogels;
Bioprinting;
Bone and Bones
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2025;39(1):100-105
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To summarize the research progress of bioactive scaffolds in the repair and regeneration of osteoporotic bone defects.
METHODS:Recent literature on bioactive scaffolds for the repair of osteoporotic bone defects was reviewed to summarize various types of bioactive scaffolds and their associated repair methods.
RESULTS:The application of bioactive scaffolds provides a new idea for the repair and regeneration of osteoporotic bone defects. For example, calcium phosphate ceramics scaffolds, hydrogel scaffolds, three-dimensional (3D)-printed biological scaffolds, metal scaffolds, as well as polymer material scaffolds and bone organoids, have all demonstrated good bone repair-promoting effects. However, in the pathological bone microenvironment of osteoporosis, the function of single-material scaffolds to promote bone regeneration is insufficient. Therefore, the design of bioactive scaffolds must consider multiple factors, including material biocompatibility, mechanical properties, bioactivity, bone conductivity, and osteogenic induction. Furthermore, physical and chemical surface modifications, along with advanced biotechnological approaches, can help to improve the osteogenic microenvironment and promote the differentiation of bone cells.
CONCLUSION:With advancements in technology, the synergistic application of 3D bioprinting, bone organoids technologies, and advanced biotechnologies holds promise for providing more efficient bioactive scaffolds for the repair and regeneration of osteoporotic bone defects.
