Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis.
10.7507/1002-1892.202408002
- Author:
Guangtao HAN
1
;
Shuo SUN
1
;
Qin WANG
1
;
Pengde KANG
1
Author Information
1. Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
- Publication Type:English Abstract
- Keywords:
Rheumatoid arthritis;
dendritic cells;
immune metabolism;
metabolic characteristics
- MeSH:
Dendritic Cells/immunology*;
Arthritis, Rheumatoid/immunology*;
Humans;
Glycolysis;
Oxidative Phosphorylation;
Lipid Metabolism;
Animals
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2024;38(12):1537-1541
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review the role of dendritic cells (DC) in immune metabolism of rheumatoid arthritis (RA).
METHODS:Literature on the role of DC in the immune metabolism of RA was extensively reviewed in recent years, and the metabolic characteristics of RA, the role of DC in RA, the correlation between the immune metabolism of DC and pathogenesis of RA, and the treatment were summarized and analyzed.
RESULTS:DC promotes the progression of RA under hypoxia, increased glycolysis, inhibition of oxidative phosphorylation, and decreased lipid metabolism. Moreover, many DCs (especially conventional DC and monocyte-derived DC) have different functions and phenotypic characteristics in RA, which are closely related to the occurrence and development of RA.
CONCLUSION:DC plays an important role in the immune metabolism of RA, and immunometabolism therapy based on DC can provide targeted therapy for the treatment of RA.
