Advantages and prospects of cell derived decellularized extracellular matrix as tissue engineering scaffolds.
10.7507/1002-1892.202404114
- Author:
Zhipo DU
1
;
Jie LIAO
2
;
Bingbing WANG
3
;
Suxiang YU
4
;
Xiaoming LI
3
Author Information
1. Department of Orthopedics, the Fourth Central Hospital of Baoding City, Baoding Hebei, 072350, P. R. China.
2. .
3. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, P. R. China.
4. Department of Pathology, the Fourth Central Hospital of Baoding City, Baoding Hebei, 072350, P. R. China.
- Publication Type:English Abstract
- Keywords:
Cell derived decellularized extracellular matrix;
tissue engineering scaffold;
tissue repair
- MeSH:
Tissue Engineering/methods*;
Tissue Scaffolds/chemistry*;
Humans;
Decellularized Extracellular Matrix/chemistry*;
Cells, Cultured;
Extracellular Matrix;
Animals;
Biocompatible Materials/chemistry*;
Cell Culture Techniques
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2024;38(11):1291-1298
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review the application of cell derived decellularized extracellular matrix (CDM) in tissue engineering.
METHODS:The literature related to the application of CDM in tissue engineering was extensively reviewed and analyzed.
RESULTS:CDM is a mixture of cells and their secretory products obtained by culturing cells in vitro for a period of time, and then the mixture is treated by decellularization. Compared with tissue derived decellularized extracellular matrix (TDM), CDM can screen and utilize pathogen-free autologous cells, effectively avoiding the possible shortcomings of TDM, such as immune response and limited sources. In addition, by selecting the cell source, controlling the culture conditions, and selecting the template scaffold, the composition, structure, and mechanical properties of the scaffold can be controlled to obtain the desired scaffold. CDM retains the components and microstructure of extracellular matrix and has excellent biological functions, so it has become the focus of tissue engineering scaffolds.
CONCLUSION:CDM is superior in the field of tissue engineering because of its outstanding adjustability, safety, and high bioactivity. With the continuous progress of technology, CDM stents suitable for clinical use are expected to continue to emerge.
