Experimental study on the treatment of postmenopausal osteoporosis with low-frequency pulsed electromagnetic fields.
10.7507/1001-5515.202501026
- Author:
Zidong AN
1
;
Liqiang WANG
1
;
Yi WU
1
;
Yongjie PANG
1
;
Keming CHEN
1
;
Yuhai GAO
1
Author Information
1. Fundmental Medicial Science Research Laboratory, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, P. R. China.
- Publication Type:Journal Article
- Keywords:
Bone formation;
Bone mineral density;
Bone resorption;
Low-frequency pulsed electromagnetic field;
Osteoporosis
- MeSH:
Female;
Animals;
Rats, Sprague-Dawley;
Osteoporosis, Postmenopausal/therapy*;
Rats;
Bone Density;
Ovariectomy;
Magnetic Field Therapy/methods*;
Electromagnetic Fields
- From:
Journal of Biomedical Engineering
2025;42(5):1054-1061
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to investigate the therapeutic efficacy of 50 Hz-0.6 mT low-frequency pulsed electromagnetic field (PEMF) on postmenopausal osteoporosis in ovariectomized rats. Thirty 3-month-old female SD rats were selected and divided into a sham operation group (Sham), an ovariectomized model group (OVX), and a low-frequency pulsed electromagnetic field (PEMF) treatment group, with 10 rats in each group. After 8 weeks, the whole-body bone mineral density (BMD) of each group of rats was measured. The treatment group began to receive PEMF stimulation for 90 minutes daily, while the OVX group only received a simulated placement without electricity. After 6 weeks of intervention, all rats were sacrificed and tested for in vitro BMD, micro-CT, biomechanics, serum biochemical indicators, and bone tissue-related proteins. The results showed that the BMD of the OVX group was significantly lower than that of the Sham group 8 weeks after surgery, indicating successful modeling. After 6 weeks of treatment, compared with the OVX group, the PEMF group exhibited significantly increased BMD in the whole body, femur, and vertebral bodies. Micro-CT analysis results showed improved bone microstructure, significantly increased maximum load and bending strength of the femur, elevated levels of serum bone formation markers, and increased expression of osteogenic-related proteins. In conclusion, this study demonstrates that daily 90-minute exposure to 50 Hz-0.6 mT PEMF effectively enhances BMD, improves bone biomechanical properties, optimizes bone microstructure, stimulates bone formation, and inhibits bone resorption in ovariectomized rats, highlighting its therapeutic potential for postmenopausal osteoporosis.
