Structural design and mechanical analysis of a "drum-shaped" balloon-expandable valve stent in expanded configuration.
10.7507/1001-5515.202505020
- Author:
Youzhi ZHAO
1
;
Qianwen HOU
2
;
Jianye ZHOU
2
;
Shiliang CHEN
1
;
Hanbing ZHANG
1
;
Aike QIAO
1
Author Information
1. Department of Biomedical Engineering, College of Chemistry and Life Sciences, Beijing University of Technology, Beijing 100124, P. R. China.
2. State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, P. R. China.
- Publication Type:Journal Article
- Keywords:
Aortic stenosis;
Balloon-expandable valve stent;
Mechanical performance;
Numerical simulation;
Structural design
- MeSH:
Stents;
Prosthesis Design;
Heart Valve Prosthesis;
Humans;
Aortic Valve/surgery*;
Stress, Mechanical;
Transcatheter Aortic Valve Replacement/instrumentation*
- From:
Journal of Biomedical Engineering
2025;42(5):945-953
- CountryChina
- Language:Chinese
-
Abstract:
Stent migration is one of the common complications following transcatheter valve implantation. This study aims to design a "drum-shaped" balloon-expandable aortic valve stent to address this issue and conduct a mechanical analysis. The implantation process of the stent was evaluated using a method that combines numerical simulation and in vitro experiments. Furthermore, the fatigue process of the stent under pulsatile cyclic loading was simulated, and its fatigue performance was assessed using a Goodman diagram. The process of the stent migrating toward the left ventricular side was simulated, and the force-displacement curve of the stent was extracted to evaluate its anti- migration performance. The results showed that all five stent models could be crimped into a 14F sheath and enabled uniform expansion of the native valve leaflets. The stress in each stent was below the ultimate stress, so no fatigue fracture occurred. As the cell height ratio decreased, the contact area fraction between the stent and the aortic root gradually decreased. However, the mean contact force and the maximum anti-migration force first decreased and then increased. Specifically, model S5 had the smallest contact area fraction but the largest mean contact force and maximum anti-migration force, reaching approximately 0.16 MPa and 10.73 N, respectively. The designed stent achieves a "drum-shaped" change after expansion and has good anti-migration performance.
