Simulation research on the influence of regular porous lattice scaffolds on bone growth.
10.7507/1001-5515.202410062
- Author:
Yutao MEN
1
;
Lele WEI
1
;
Baibing HU
1
;
Pujun HAO
1
;
Chunqiu ZHANG
1
Author Information
1. Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China.
- Publication Type:Journal Article
- Keywords:
Bone growth;
Lattice porous scaffold;
Pore size;
Porosity;
Secondary development
- MeSH:
Tissue Scaffolds/chemistry*;
Porosity;
Finite Element Analysis;
Tissue Engineering/methods*;
Computer Simulation;
Bone Development;
Osteogenesis;
Humans;
Cell Proliferation
- From:
Journal of Biomedical Engineering
2025;42(4):808-816
- CountryChina
- Language:Chinese
-
Abstract:
To assess the implantation effectiveness of porous scaffolds, it is essential to consider not only their mechanical properties but also their biological performance. Given the high cost, long duration and low reproducibility of biological experiments, simulation studies as a virtual alternative, have become a widely adopted and efficient evaluation method. In this study, based on the secondary development environment of finite element analysis software, the strain energy density growth criterion for bone tissue was introduced to simulate and analyze the cell proliferation-promoting effects of four different lattice porous scaffolds under cyclic compressive loading. The biological performance of these scaffolds was evaluated accordingly. The computational results indicated that in the early stages of bone growth, the differences in bone tissue formation among the scaffold groups were not significant. However, as bone growth progressed, the scaffold with a porosity of 70% and a pore size of 900 μm demonstrated markedly superior bone formation compared to other porosity groups and pore size groups. These results suggested that the scaffold with a porosity of 70% and a pore size of 900 μm was most conducive to bone tissue growth and could be regarded as the optimal structural parameter for bone repair scaffold. In conclusion, this study used a visualized simulation approach to pre-evaluate the osteogenic potential of porous scaffolds, aiming to provide reliable data support for the optimized design and clinical application of implantable scaffolds.
