Effect of 40 Hz pulsed magnetic field on mitochondrial dynamics and heart rate variability in dementia mice.
10.7507/1001-5515.202501061
- Author:
Lifan ZHANG
1
;
Duyan GENG
2
;
Guizhi XU
2
;
Hongxia AN
1
Author Information
1. School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
2. State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, P. R. China.
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
Extremely low frequency magnetic field;
Heart rate variability;
Mitochondrial dynamics
- MeSH:
Animals;
Heart Rate/physiology*;
Mice;
Alzheimer Disease/therapy*;
Mice, Transgenic;
Mitochondrial Dynamics/radiation effects*;
Magnetic Field Therapy/methods*;
Magnetic Fields;
Disease Models, Animal;
Mitochondria;
Male;
Maze Learning;
Cognition;
Dementia/therapy*
- From:
Journal of Biomedical Engineering
2025;42(4):707-715
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is the most common degenerative disease of the nervous system. Studies have found that the 40 Hz pulsed magnetic field has the effect of improving cognitive ability in AD, but the mechanism of action is not clear. In this study, APP/PS1 double transgenic AD model mice were used as the research object, the water maze was used to group dementia, and 40 Hz/10 mT pulsed magnetic field stimulation was applied to AD model mice with different degrees of dementia. The behavioral indicators, mitochondrial samples of hippocampal CA1 region and electrocardiogram signals were collected from each group, and the effects of 40 Hz pulsed magnetic field on mouse behavior, mitochondrial kinetic indexes and heart rate variability (HRV) parameters were analyzed. The results showed that compared with the AD group, the loss of mitochondrial crest structure was alleviated and the mitochondrial dynamics related indexes were significantly improved in the AD + stimulated group ( P < 0.001), sympathetic nerve excitation and parasympathetic nerve inhibition were improved, and the spatial cognitive memory ability of mice was significantly improved ( P < 0.05). The preliminary results of this study show that 40 Hz pulsed magnetic field stimulation can improve the mitochondrial structure and mitochondrial kinetic homeostasis imbalance of AD mice, and significantly improve the autonomic neuromodulation ability and spatial cognition ability of AD mice, which lays a foundation for further exploring the mechanism of ultra-low frequency magnetic field in delaying the course of AD disease and realizing personalized neurofeedback therapy for AD.
