Prefrontal dysfunction and mismatch negativity in adolescent depression: A multimodal fNIRS-ERP study.
10.7507/1001-5515.202503053
- Author:
Hongyi SUN
1
;
Lin ZHANG
2
;
Jing LI
3
;
Zhenhua LI
3
;
Jiaxi HUANG
3
;
Zhong ZHENG
1
;
Ke ZOU
1
Author Information
1. Neurobiological Laboratory, West China Hospital of Sichuan University, Chengdu 610041, P. R. China.
2. The Department of Rehabilitation Medicine, First People's Hospital of Jintang County, Chengdu 610499, P. R. China.
3. Neurobiological Laboratory, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian 361000, P. R. China.
- Publication Type:Journal Article
- Keywords:
Adolescents;
Depression;
Event-related potentials;
Functional near-infrared spectroscopy;
Mismatch negativity
- MeSH:
Humans;
Spectroscopy, Near-Infrared/methods*;
Adolescent;
Prefrontal Cortex/physiopathology*;
Evoked Potentials/physiology*;
Depression/physiopathology*;
Female;
Male;
Oxyhemoglobins;
Electroencephalography
- From:
Journal of Biomedical Engineering
2025;42(4):701-706
- CountryChina
- Language:Chinese
-
Abstract:
Early identification of adolescent depression requires objective biomarkers. This study investigated the functional near-infrared spectroscopy (fNIRS) activation patterns and mismatch negativity (MMN) characteristics in adolescents with first-episode mild-to-moderate depression. We enrolled 33 patients and 33 matched healthy controls, measuring oxyhemoglobin (Oxy-Hb) concentration in the frontal cortex during verbal fluency tasks via fNIRS, and recording MMN latency/amplitude at Fz/Cz electrodes using event-related potentials (ERP). Compared with healthy controls, the depression group showed significantly prolonged MMN latency [Fz: (227.88 ± 31.08) ms vs. (208.70 ± 25.35) ms, P < 0.01; Cz: (223.73 ± 29.03) ms vs. (204.18 ± 22.43) ms, P < 0.01], and obviously reduced Fz amplitude [(2.42 ± 2.18) μV vs. (5.65 ± 5.59) μV, P = 0.03]. A significant positive correlation was observed between MMN latencies at Fz and Cz electrodes ( P < 0.01). Oxy-Hb in left frontopolar prefrontal channels (CH15/17) was significantly decreased in patient group ( P < 0.05). Our findings suggest that adolescents with depression exhibit hypofunction in the left prefrontal cortex and impaired automatic sensory processing. The combined application of fNIRS and ERP techniques may provide an objective basis for early clinical identification.
