Research progress on the manufacturing technology of hollow microneedles.
10.7507/1001-5515.202408024
- Author:
Shengshuo ZHOU
1
;
Huajian ZHOU
1
;
Xiaoyu DU
1
;
Ziye YU
1
;
Tongle XU
1
;
Shun ZHAO
1
;
Peiqiang SU
2
;
Leian ZHANG
1
;
Guangyang FU
1
;
Xuelei LIU
1
Author Information
1. School of Mechanical Engineering, Shandong University of Technology , Zibo, Shandong 255000, P. R. China.
2. Shandong Huiyu Auto Parts Co., Ltd., Binzhou, Shandong 251702, P. R. China.
- Publication Type:English Abstract
- Keywords:
Hollow microneedle;
Hollow microneedle material;
Manufacturing technology;
Microneedle;
Process route
- MeSH:
Printing, Three-Dimensional;
Needles;
Humans;
Drug Delivery Systems/methods*;
Equipment Design;
Microinjections/methods*
- From:
Journal of Biomedical Engineering
2025;42(2):423-430
- CountryChina
- Language:Chinese
-
Abstract:
Drug administration via hollow microneedles (HMN) have the advantages of painlessness, avoidance of first-pass effect, capability of sustained infusion, and no need for professional personnel operation. In addition, HMN can also be applied in the fields of body fluid extraction and biosensors, showing broad application prospects. However, traditional manufacturing technologies cannot meet the demand for low-cost mass production of HMN, limiting its widespread application. This paper reviews the main manufacturing technologies used for HMN in recent years, which include photolithography and etching, laser etching, sputtering and electroplating, micro-molding, three-dimensional (3D) printing and drawing lithography. It further analyzes the characteristics and limitations of existing manufacturing technologies and points out that the combination of various manufacturing technologies can improve production efficiency to a certain extent. In addition, this paper looks forward to the future trends of HMN manufacturing technology and proposes possible directions for its development. In conclusion, it is expected that this review can provide new ideas and references for follow-up research.
