Research progress on repetitive transcranial magnetic stimulation for improving depression in Parkinson's disease.
10.7507/1001-5515.202410040
- Author:
Wei LU
1
;
Baofeng HE
2
;
Juan LI
1
;
Mingming WEN
1
;
Min ZHANG
3
Author Information
1. Department of Rehabilitation Medicine, Gansu Provincial Hospital, Lanzhou 730000, P. R. China.
2. College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, P. R. China.
3. Second Ward of Department of Neurology, Gansu Provincial Hospital, Lanzhou 730000, P. R. China.
- Publication Type:English Abstract
- Keywords:
Depression;
Parkinson 's disease;
Repetitive transcranial magnetic stimulation
- MeSH:
Humans;
Parkinson Disease/psychology*;
Transcranial Magnetic Stimulation/methods*;
Depression/etiology*
- From:
Journal of Biomedical Engineering
2025;42(2):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease is a neurodegenerative disease that mostly occurs in middle-aged and elderly people. It is characterized by progressive loss of dopaminergic neurons in the substantia nigra and aggregation of Lewy bodies, resulting in a series of motor symptoms and non-motor symptoms. Depression is the most important manifestation of non-motor symptoms, which seriously affects the quality of life of patients. Clinicians often use antidepressant drugs to improve the depressive symptoms of patients with Parkinson 's disease, but it is still urgent to solve the problems of drug side effects and drug resistance caused by such methods. Repetitive transcranial magnetic stimulation is a safe and non-invasive neuromodulation technique that can change the excitability of the corticospinal tract, induce the release of dopamine and other neurotransmitters, and further improve the depressive symptoms of patients with Parkinson 's disease. Based on this, this paper discusses and summarizes the research progress on the efficacy and potential mechanism of repetitive transcranial magnetic stimulation for improving depression in Parkinson 's disease at home and abroad, in order to provide reference for related clinical application research.
