A simulation study of nerve fiber activation in the lumbar segment under kilohertz-frequency transcutaneously spinal cord stimulation.
10.7507/1001-5515.202407004
- Author:
Qi XU
1
;
Xinru LI
1
;
Zhixin LU
1
;
Yongchao WU
2
Author Information
1. School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan 430074, P. R. China.
2. Department of Rehabilitation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China.
- Publication Type:Journal Article
- Keywords:
Kilohertz frequency;
Neuron model;
Spinal fiber;
Transcutaneous spinal cord stimulation
- MeSH:
Humans;
Spinal Cord Stimulation/methods*;
Nerve Fibers/physiology*;
Finite Element Analysis;
Spinal Cord/physiology*;
Computer Simulation;
Spinal Cord Injuries/physiopathology*;
Lumbosacral Region;
Lumbar Vertebrae;
Transcutaneous Electric Nerve Stimulation/methods*;
Models, Neurological
- From:
Journal of Biomedical Engineering
2025;42(2):300-307
- CountryChina
- Language:Chinese
-
Abstract:
Clinical trials have demonstrated that kilohertz-frequency transcutaneous spinal cord stimulation (TSCS) can be used to facilitate the recovery of sensory-motor function for patients with spinal cord injury, whereas the neural mechanism of TSCS is still undetermined so that the choice of stimulation parameters is largely dependent on the clinical experience. In this paper, a finite element model of transcutaneous spinal cord stimulation was used to calculate the electric field distribution of human spinal cord segments T 12 to L 2, whereas the activation thresholds of spinal fibers were determined by using a double-cable neuron model. Then the variation of activation thresholds was obtained by varying the carrier waveform, the interphase delay, the modulating frequency, and the modulating pulse width. Compared with the sinusoidal carrier, the usage of square carrier could significantly reduce the activation threshold of dorsal root (DR) fibers. Moreover, the variation of activation thresholds was no more than 1 V due to the varied modulating frequency and decreases with the increased modulating pulse width. For a square carrier at 10 kHz modulated by rectangular pulse with the frequency of 50 Hz and the pulse width of 1 ms, the lowest activation thresholds of DR fibers and dorsal column fibers were 27.6 V and 55.8 V, respectively. An interphase delay of 5 μs was able to reduce the activation thresholds of the DR fibers to 20.1 V. The simulation results can lay a theoretical foundation on the selection of TSCS parameters in clinical trials.
