Quantitative analysis of transcranial temporal interference stimulation in rodents: A simulation study on electrode configurations.
10.7507/1001-5515.202411054
- Author:
Xiaoxi LIU
1
;
Hongli YU
1
;
Fushuai GOU
1
;
Boai DU
1
;
Pengyi LU
1
;
Chunfang WANG
2
Author Information
1. School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
2. Rehabilitation Medical Department, Tianjin Union Medical Centre, Tianjin 300121, P. R. China.
- Publication Type:Journal Article
- Keywords:
Electrode configuration;
Temporal interference;
Transcranial electrical stimulation
- MeSH:
Animals;
Transcranial Direct Current Stimulation/instrumentation*;
Electrodes;
Mice;
Computer Simulation;
Finite Element Analysis;
Brain/physiology*
- From:
Journal of Biomedical Engineering
2025;42(2):280-287
- CountryChina
- Language:Chinese
-
Abstract:
Transcranial temporal interference stimulation (tTIS) is a novel non-invasive transcranial electrical stimulation technique that achieves deep brain stimulation through multiple electrodes applying electric fields of different frequencies. Current studies on the mechanism of tTIS effects are primarily based on rodents, but experimental outcomes are often significantly influenced by electrode configurations. To enhance the performance of tTIS within the limited cranial space of rodents, we proposed various electrode configurations for tTIS and conducted finite element simulations using a realistic mouse model. Results demonstrated that ventral-dorsal, four-channel bipolar, and two-channel configurations performed best in terms of focality, diffusion of activated brain regions, and scalp impact, respectively. Compared to traditional transcranial direct current stimulation (tDCS), these configurations improved by 94.83%, 50.59%, and 3 514.58% in the respective evaluation metrics. This study provides a reference for selecting electrode configurations in future tTIS research on rodents.
