Research on a portable electrical impedance tomography system for evaluating blood compatibility of biomaterials.
10.7507/1001-5515.202410058
- Author:
Piao PENG
1
;
Huaihao CHEN
2
;
Bo CHE
2
;
Xuan LI
2
;
Chunjian FAN
2
;
Lei LIU
2
;
Teng LUO
2
;
Linhong DENG
2
Author Information
1. College of Microelectronics and Control Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China.
2. Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, P. R. China.
- Publication Type:Journal Article
- Keywords:
Biomaterials;
Blood compatibility;
Coagulation;
Electrical impedance tomography;
Hemolysis
- MeSH:
Electric Impedance;
Animals;
Tomography/instrumentation*;
Biocompatible Materials;
Materials Testing/instrumentation*;
Cattle;
Titanium;
Alloys;
Prostheses and Implants
- From:
Journal of Biomedical Engineering
2025;42(2):219-227
- CountryChina
- Language:Chinese
-
Abstract:
The evaluation of blood compatibility of biomaterials is crucial for ensuring the clinical safety of implantable medical devices. To address the limitations of traditional testing methods in real-time monitoring and electrical property analysis, this study developed a portable electrical impedance tomography (EIT) system. The system uses a 16-electrode design, operates within a frequency range of 1 to 500 kHz, achieves a signal to noise ratio (SNR) of 69.54 dB at 50 kHz, and has a data collection speed of 20 frames per second. Experimental results show that the EIT system developed in this study is highly consistent with a microplate reader ( R 2=0.97) in detecting the hemolytic behavior of industrial-grade titanium (TA3) and titanium alloy-titanium 6 aluminum 4 vanadium (TC4) in anticoagulated bovine blood. Additionally, with the support of a multimodal image fusion Gauss-Newton one-step iterative algorithm, the system can accurately locate and monitor in real-time the dynamic changes in blood permeation and coagulation caused by TC4 in vivo. In conclusion, the EIT system developed in this study provides a new and effective method for evaluating the blood compatibility of biomaterials.
