Preparation of collagen-polysaccharide composite hydrogels and research progress in biomedical applications.
10.7507/1001-5515.202407008
- Author:
Meihong XU
1
;
Enxiang JIAO
1
;
Ziru SUN
1
;
Kunshan YUAN
2
;
Xiangyi FENG
1
;
Yuanbiao LIU
1
;
Kai GUO
1
;
Kun LI
1
;
Haijun ZHANG
1
;
Xuehai ZHANG
1
Author Information
1. College of Materials Science and Engineering, Shandong University of Technology, Zibo, Shandong 255000, P. R. China.
2. National Local Joint Engineering Laboratory of Biomedical Material Modification Technology, Dezhou, Shandong 253000, P. R. China.
- Publication Type:English Abstract
- Keywords:
Biomedicine;
Collagen;
Hydrogels;
Polysaccharide
- MeSH:
Hydrogels/chemical synthesis*;
Collagen/chemistry*;
Polysaccharides/chemistry*;
Alginates/chemistry*;
Hyaluronic Acid/chemistry*;
Chitosan/chemistry*;
Biocompatible Materials/chemistry*;
Humans;
Tissue Engineering/methods*;
Cellulose/chemistry*;
Tissue Scaffolds
- From:
Journal of Biomedical Engineering
2024;41(6):1286-1292
- CountryChina
- Language:Chinese
-
Abstract:
Collagen contains abundant cell binding motifs, which are conducive to adhesion, migration, and differentiation, maintain cell vitality and promote cell proliferation. However, pure collagen hydrogel has some shortcomings such as poor mechanical properties, poor thermal stability and fast degradation. Numerous studies have shown that the properties of collagen can be improved by combining it with natural polysaccharides such as alginate, chitosan, hyaluronic acid and cellulose. In this paper, the research status and biological application fields of four kinds of composite hydrogels, including collagen-alginate composite hydrogels, collagen-chitosan hydrogels, collagen-hyaluronic acid hydrogels and collagen-cellulose hydrogels, were summarized. The common preparation methods of four kinds of composite hydrogels were introduced, and the future development direction of collagen-based composite hydrogels was prospected.
