Controllability and predictability of riboflavin-ultraviolet A collagen cross-linking: advances in experimental techniques and theoretical research.
10.7507/1001-5515.202402017
- Author:
Xiaona LIU
1
;
Xiaona LI
1
;
Weiyi CHEN
1
Author Information
1. Collage of Artificial Intelligence, Taiyuan University of Technology, Taiyuan 030024, P. R. China.
- Publication Type:English Abstract
- Keywords:
Controllability;
Cross-linking effect;
Depth-dependent cross-linking;
Riboflavin-ultraviolet A collagen cross-linking
- MeSH:
Riboflavin/pharmacology*;
Humans;
Collagen/radiation effects*;
Ultraviolet Rays;
Cross-Linking Reagents;
Corneal Diseases/drug therapy*;
Photosensitizing Agents/therapeutic use*
- From:
Journal of Biomedical Engineering
2025;42(1):212-218
- CountryChina
- Language:Chinese
-
Abstract:
Riboflavin-ultraviolet A (UVA) collagen cross-linking has not only achieved good clinical efficacy in the treatment of corneal diseases such as dilatation keratopathy, bullae keratopathy, infectious keratopathy, and in the combined treatment of corneal refractive surgeries, but also its efficacy and safety in scleral collagen cross-linking have been initially confirmed. To better promote the application of cross-linking in the clinical treatment of corneal and scleral diseases, exploring controllability and predictability of the surgical efficacy are both important for evaluating the surgical efficacy and personalized precision treatment. In this paper, the progress on the cross-linking depth of riboflavin-UVA collagen cross-linking, and its relationship with the cross-linking effect will be reviewed. It will provide the reference for further application of this procedure in ophthalmology clinics.
