Development of oral preparations of poorly soluble drugs based on polymer supersaturated self-nanoemulsifying drug delivery technology.
10.19540/j.cnki.cjcmm.20250321.303
- Author:
Xu-Long CHEN
1
;
Jiang-Wen SHEN
1
;
Wei-Wei ZHA
1
;
Jian-Yun YI
1
;
Lin LI
1
;
Zhang-Ting LAI
2
;
Zheng-Gen LIAO
2
;
Ye ZHU
1
;
Yue-Er CHENG
1
;
Cheng LI
1
Author Information
1. School of Clinical Medicine, Jiujiang University Jiujiang 332000, China.
2. Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
- Publication Type:English Abstract
- Keywords:
development of oral drug delivery system;
polymer supersaturated self-nanoemulsion;
poorly soluble drug;
stability
- MeSH:
Solubility;
Administration, Oral;
Polymers/chemistry*;
Drug Delivery Systems/methods*;
Humans;
Emulsions/chemistry*;
Biological Availability;
Animals;
Pharmaceutical Preparations/administration & dosage*
- From:
China Journal of Chinese Materia Medica
2025;50(16):4471-4482
- CountryChina
- Language:Chinese
-
Abstract:
Poor water solubility is the primary obstacle preventing the development of many pharmacologically active compounds into oral preparations. Self-nanoemulsifying drug delivery systems(SNEDDS) have become a widely used strategy to enhance the oral bioavailability of poorly soluble drugs by inducing a supersaturated state, thereby improving their apparent solubility and dissolution rate. However, the supersaturated solutions formed in SNEDDS are thermodynamically unstable systems with solubility levels exceeding the crystalline equilibrium solubility, making them prone to drug precipitation in the gastrointestinal tract and ultimately hindering drug absorption. Therefore, maintaining a stable supersaturated state is crucial for the effective delivery of poorly soluble drugs. Incorporating polymers as precipitation inhibitors(PPIs) into the formulation of supersaturated self-nanoemulsifying drug delivery systems(S-SNEDDS) can inhibit drug aggregation and crystallization, thus maintaining a stable supersaturated state. This has emerged as a novel preparation strategy and a key focus in SNEDDS research. This review explores the preparation design of SNEDDS and the technical challenges involved, with a particular focus on polymer-based S-SNEDDS for enhancing the solubility and oral bioavailability of poorly soluble drugs. It further elucidates the mechanisms by which polymers participate in transmembrane transport, summarizes the principles by which polymers sustain a supersaturated state, and discusses strategies for enhancing drug absorption. Altogether, this review provides a structured framework for the development of S-SNEDDS preparations with stable quality and reduced development risk, and offers a theoretical reference for the application of S-SNEDDS technology in improving the oral bioavailability of poorly soluble drugs.
