Research progress on molecular mechanisms of ginsenosides in alleviating acute lung injury.
10.19540/j.cnki.cjcmm.20250331.303
- Author:
Han-Yang ZHAO
1
;
Xun-Jiang WANG
1
;
Qiong-Wen XUE
1
;
Bao-Lian XU
1
;
Xu WANG
1
;
Shu-Sheng LAI
2
;
Ming CHEN
2
;
Li YANG
1
;
Zheng-Tao WANG
1
;
Li-Li DING
1
Author Information
1. Shanghai Key Laboratory of Compound Chinese Medicines,the MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai R&D Center for Standardization of Traditional Chinese Medicines Shanghai 201203, China.
2. Guangxi Zhongheng Innovative Pharmaceutical Research Co., Ltd. Nanning 530032, China Guangxi Key Laboratory of Comprehensive Utilization Technology of Pseudo-ginseng Wuzhou 543002, China.
- Publication Type:English Abstract
- Keywords:
Ginseng Radix et Rhizoma;
acute lung injury;
anti-inflammation;
ginsenosides;
molecular mechanisms
- MeSH:
Ginsenosides/pharmacology*;
Humans;
Acute Lung Injury/immunology*;
Animals;
Panax/chemistry*;
Drugs, Chinese Herbal
- From:
China Journal of Chinese Materia Medica
2025;50(16):4451-4470
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury(ALI) is a critical clinical condition primarily characterized by refractory hypoxemia and infiltration of inflammatory cells in lung tissue, which can progress into a more severe form known as acute respiratory distress syndrome(ARDS). Immune cells and inflammatory cytokines play important roles in the progression of the disease. Due to its unclear pathogenesis and the lack of effective clinical treatments, ALI is associated with a high mortality rate and severely affects patients' quality of life, making the search for effective therapeutic agents particularly urgent. Ginseng Radix et Rhizoma, the dried root of the perennial herb Panax ginseng from the Araliaceae family, contains active ingredients such as saponins and polysaccharides, which possess various pharmacological effects including anti-tumor activity, immune regulation, and metabolic modulation. In recent years, studies have shown that ginsenosides exhibit notable effects in reducing inflammation, ameliorating epithelial and endothelial cell injury, and providing anticoagulant action, indicating their comprehensive role in alleviating lung injury. This review summarizes the pathogenesis of ALI and the molecular mechanisms through which ginsenosides act at different stages of ALI development. The aim is to provide a scientific reference for the development of ginsenoside-based drugs targeting ALI, as well as a theoretical basis for the clinical application of Ginseng Radix et Rhizoma in the treatment of ALI.
