Research progress and exploration of traditional Chinese medicine in treatment of sepsis-acute lung injury by inhibiting pyroptosis.
10.19540/j.cnki.cjcmm.20250423.501
- Author:
Wen-Yu WU
1
;
Nuo-Ran LI
2
;
Kai WANG
1
;
Xin JIAO
2
;
Wan-Ning LAN
1
;
Yun-Sheng XU
1
;
Lin WANG
1
;
Jing-Nan LIN
1
;
Rui CHEN
3
;
Rui-Feng ZENG
3
;
Jun LI
1
Author Information
1. the First Clinical Medical School, Guangzhou University of Chinese Medicine Guangzhou 510405, China the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405, China Guangdong Clinical Research Academy of Chinese Medicine Guangzhou 510405, China.
2. the Second Clinical Medical School, Guangzhou University of Chinese Medicine Guangzhou 510405, China the Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510120, China.
3. the Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510120, China Guangdong Provincial Key Laboratory for Research on Emergency of Traditional Chinese Medicine Guangzhou 510120, China.
- Publication Type:English Abstract
- Keywords:
acute lung injury;
molecular mechanism;
pyroptosis;
sepsis;
traditional Chinese medicine
- MeSH:
Pyroptosis/drug effects*;
Humans;
Sepsis/genetics*;
Acute Lung Injury/physiopathology*;
Animals;
Drugs, Chinese Herbal/therapeutic use*;
Medicine, Chinese Traditional;
Inflammasomes/metabolism*;
NLR Family, Pyrin Domain-Containing 3 Protein/genetics*
- From:
China Journal of Chinese Materia Medica
2025;50(16):4425-4436
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a systemic inflammatory response caused by severe infection or trauma, and is one of the common causes of acute lung injury(ALI) and acute respiratory distress syndrome(ARDS). Sepsis-acute lung injury(SALI) is a critical clinical condition with high morbidity and mortality. Its pathogenesis is complex and not yet fully understood, and there is currently a lack of targeted and effective treatment options. Pyroptosis, a novel form of programmed cell death, plays a key role in the pathological process of SALI by activating inflammasomes and releasing inflammatory factors, making it a potential therapeutic target. In recent years, the role of traditional Chinese medicine(TCM) in regulating signaling pathways related to pyroptosis through multi-components and multi-targets has attracted increasing attention. TCM may intervene in pyroptosis by inhibiting the activation of NLRP3 inflammasomes and regulating the expression of Caspase family proteins, thus alleviating inflammatory damage in lung tissues. This paper systematically reviews the molecular regulatory network of pyroptosis in SALI and explores the potential mechanisms and research progress on TCM intervention in cellular pyroptosis. The aim is to provide new ideas and theoretical support for basic research and clinical treatment strategies of TCM in SALI.
