Mechanism of traditional Chinese medicine treatment of hepatic fibrosis by restoring circadian rhythms.
10.19540/j.cnki.cjcmm.20250417.601
- Author:
Meng-Ru ZHANG
1
;
Ruo-Nan JIANG
2
;
Shu-Hua XIONG
2
;
Hong-Yan WU
3
;
De-Song KONG
2
;
Li CHEN
4
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Nanjing 210022, China.
2. Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Nanjing 210022, China.
3. Jiangsu Vocational College of Medicine Yancheng 224005, China.
4. School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
- Publication Type:English Abstract
- Keywords:
circadian rhythm;
hepatic fibrosis;
traditional Chinese medicine
- MeSH:
Humans;
Liver Cirrhosis/metabolism*;
Drugs, Chinese Herbal/therapeutic use*;
Circadian Rhythm/drug effects*;
Animals;
Medicine, Chinese Traditional;
Hepatic Stellate Cells/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(16):4407-4414
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is a key pathological process in the development of chronic liver disease to cirrhosis, and its core mechanism involves the activation of hepatic stellate cells(HSC) and abnormal deposition of extracellular matrix(ECM). Although existing treatments, such as antiviral drugs, can delay disease progression, they have the problem of single therapeutic targets and cannot reverse fibrosis. Accordingly, multidimensional intervention strategies are urgently needed. Recent studies have shown that circadian rhythm disorders aggravate hepatic fibrosis by regulating metabolism, immunity, and inflammation. Traditional Chinese medicine(TCM) plays a unique role in restoring the circadian clock via multi-target and holistic regulation. This paper establishes a three-dimensional network by systematically integrating biological clock, metabolism, and immunity for the first time to elucidate the scientific connotation of the theory of time-concerned treatment of TCM, and proposes a new strategy for the development of time-targeted compound prescriptions, providing innovative ideas for the treatment of hepatic fibrosis.
