Study on anti-inflammatory components from Melicope pteleifolia.
10.19540/j.cnki.cjcmm.20250506.201
- Author:
He-Lin WEI
1
;
Tao WANG
2
;
Jing-Jing SUN
2
;
Zhi-Qiang HUANG
2
;
Yi-Ze XIAO
2
;
Jun LI
3
;
Peng-Fei TU
4
Author Information
1. Luzhou Vocational and Technical College Luzhou 646000, China.
2. Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine,Beijing University of Chinese Medicine Beijing 102488, China.
3. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences, Peking University Health Science Center Beijing 100191, China.
4. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences, Peking University Health Science Center Beijing 100191, China Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine,Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
Melicope pteleifolia;
anti-inflammatory activity;
chemical component;
structure elucidation
- MeSH:
Anti-Inflammatory Agents/isolation & purification*;
Mice;
Animals;
Rutaceae/chemistry*;
Drugs, Chinese Herbal/isolation & purification*;
Macrophages/immunology*;
Nitric Oxide/immunology*
- From:
China Journal of Chinese Materia Medica
2025;50(15):4275-4283
- CountryChina
- Language:Chinese
-
Abstract:
Melicope pteleifolia is a plant belonging to the Melicope genus of the Rutaceae family. Known for a bitter taste and cold nature, its stems and tender branches with leaves possess properties of clearing heat, detoxifying, dispelling wind, and removing dampness and can be used to treat sore throat, malaria, jaundice hepatitis, rheumatic bone pain, eczema, dermatitis, and sores and ulcers. In this study, 19 compounds were isolated from the chloroform and n-butanol extracts of M. pteleifolia leaves by using liquid chromatography-mass spectrometry(LC-MS) and proton nuclear magnetic resonance(~1H-NMR)-guided separation techniques. The compounds were identified as isoleptonol(1), leptaones B-E(2-5), friedelin(6), evodionol(7), ethyl p-hydroxybenzoate(8), litseachromolaevane A(9), quercetin-7,3',4'-trimethyl ether(10), kokusaginin(11), 8-(1-hydroxyethyl)-5,6,7-trimethoxy-2,2-dimethyl-2H-1-benzopyran(12), ethyl p-hydroxycinnamate(13), 3-hydroxy-9-methyl-6H-benzo\[c\]chromen-6-one(14), agrimonolide(15), 7-hydroxycoumarin(16), scopoletin(17), isoscutellarein(18), and agrimonolide 6-O-glucoside(19). Among these, the new compounds included one chromene and four meroterpenoid(1-5). The anti-inflammatory activities of the newly identified compounds 1-5 were screened in vitro, showing that the five compounds(1-5) exhibited inhibitory effects on nitric oxide(NO) production in BV2 cells induced by lipopolysaccharide(LPS)/interferon(IFN)-γ, with IC_(50) values ranging from 12.25 to 36.48 μmol·L~(-1).
