Polarized light microscopic mineral phase authentication and health risk assessment of raw and calcined fossil mineral Chinese medicinal material Draconis Os.
10.19540/j.cnki.cjcmm.20250428.101
- Author:
Yan-Qiong PAN
1
;
Zheng LIU
2
;
Li-Wen ZHENG
3
;
Ying ZHANG
2
;
Liu ZHOU
2
;
Xi-Long QIAN
2
;
Fang FANG
2
;
Xiao WU
4
;
Sheng-Jin LIU
2
Author Information
1. State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine Nanjing 210023, China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,College of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China Taikang Xianlin Drum Tower Hospital Nanjing 210023, China.
2. State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine Nanjing 210023, China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,College of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
3. State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine Nanjing 210023, China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,College of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China Nanjing Integrated Traditional Chinese and Western Medicine Hospital Nanjing 210014, China.
4. School of Medicine, Nanjing University of Chinese Medicine Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
Draconis Os;
ICP-MS;
apatite;
calcined Draconis Os;
healthy risk assessment;
microscopic characteristics;
mineral Chinese medicinal materials
- MeSH:
Drugs, Chinese Herbal/analysis*;
Risk Assessment;
Minerals/chemistry*;
Fossils;
Humans;
Drug Contamination;
Mass Spectrometry
- From:
China Journal of Chinese Materia Medica
2025;50(15):4238-4247
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to investigate the polarized microscopic mineral phase characteristics, inorganic element content, and potential health risks associated with the intake of raw and calcined fossil mineral Chinese medicinal material Draconis Os. Microscopy was employed to observe the mineralogical characteristics of Draconis Os and compare the microscopic features and phase composition of raw and calcined Draconis Os under monochromatic and orthogonal polarized light. Inductively coupled plasma mass spectrometry(ICP-MS) was employed to determine the content of 30 inorganic elements. Health risk assessment was conducted by calculating the single pollution index(P_i), average daily intake of elements for adults(ADI), target hazard quotient(THQ), non-carcinogenic assessment method-hazard quotient(HQ), and the carcinogenic risk of elements(CR). The results indicated that under monochromatic polarized light, the Draconis Os powder sections exhibited light gray-brown to gray-brown irregular fragments, some with undulating textures that were slightly curved. Under crossed polarized light, they appeared dark gray, grayish-white, and yellowish-white. Clear apatite was visible in the ground sections of Draconis Os under crossed polarized light. P_i results indicated that Draconis Os samples were free from contamination and were of good quality. According to the maximum allowable limits of heavy metals stipulated in ISO Traditional Chinese Medicine: Determination of heavy metals in herbal medicines used in Traditional Chinese Medicine, ADI, THQ, HQ, and CR were taken as assessment indicators. Only the THQ value for As(arsenic) in raw Draconis Os was greater than 1, while the THQ values for other heavy metal elements in the Draconis Os samples were all less than 1. The study demonstrates that the primary mineral phase of raw and calcined Draconis Os is apatite, with some samples co-existing with calcite, which can serve as one of the means for quality control of Draconis Os. The elemental analysis results from ICP-MS provide scientific evidence for the safety assessment of Draconis Os, indicating that Draconis Os is safe in clinical application.
