Research progress on biosynthesis and metabolic regulation of flavonoids in Ginkgo biloba.
10.19540/j.cnki.cjcmm.20250510.201
- Author:
Yuan-Jia LI
1
;
Jian-Feng GONG
2
;
Bin LI
1
;
Xu LU
3
Author Information
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
2. Hunan Huabaotong Pharmaceutical Co., Ltd. Changsha 410331, China Wepon Pharmaceutical Group Hangzhou Pharmaceutical Technology Co., Ltd. Hangzhou 310012, China.
3. School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing 100700, China.
- Publication Type:English Abstract
- Keywords:
Ginkgo biloba;
biosynthetic pathway;
flavonoids;
metabolic regulation
- MeSH:
Ginkgo biloba/chemistry*;
Flavonoids/biosynthesis*;
Gene Expression Regulation, Plant;
Plant Proteins/genetics*;
Biosynthetic Pathways
- From:
China Journal of Chinese Materia Medica
2025;50(15):4201-4208
- CountryChina
- Language:Chinese
-
Abstract:
Ginkgo biloba, an ancient relict plant, holds a lengthy medicinal tradition in China. The leaves and seeds of this remarkable species contain flavonoids, a class of active compounds that offer a multitude of pharmacological advantages. The understanding of the synthesis process of these flavonoids can be deepened substantially by elucidating their biosynthetic pathway and metabolic regulation mechanisms. This can thereby provide a foundation for achieving precise regulation of flavonoid biosynthesis, which is of great significance for improving the production efficiency and quality of flavonoids in G. biloba. This review comprehensively summarizes research advancements in metabolomics, genomics, and transcriptomics of flavonoids in G. biloba, aiming to establish a thorough academic framework. It examines key enzymes in the biosynthetic pathway of flavonoids in G. biloba and their functions, highlighting their crucial roles in flavonoid production. Additionally, it outlines transcriptional regulation mechanisms associated with flavonoid in G. biloba biosynthesis, focusing on transcription factors responsive to environmental cues and their regulatory networks that modulate flavonoid gene expression. These insights offer a theoretical foundation for precise control of G. biloba flavonoid production. By amalgamating these diverse research findings, this review aims to establish a robust theoretical groundwork for future studies on biosynthesis and efficient utilization of flavonoids in G. biloba.
