Research progress in traditional Chinese medicine treatment of kidney-Yang deficiency syndrome by regulating neuro-endocrine-immune system.
10.19540/j.cnki.cjcmm.20250407.601
- Author:
Xiao YANG
1
;
Jia-Geng GUO
1
;
Yu DUAN
2
;
Zhen-Dong QIU
1
;
Min-Qi CHEN
1
;
Wei WEI
1
;
Xiao-Tao HOU
1
;
Er-Wei HAO
1
;
Jia-Gang DENG
1
Author Information
1. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Guangxi University of Chinese Medicine Nanning 530200, China University Engineering Research Center of Reutilization of Traditional Chinese Medicine Resources in Guangxi,Guangxi University of Chinese Medicine Nanning 530200, China Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases, Guangxi University of Chinese Medicine Nanning 530200, China Guangxi University of Chinese Medicine Nanning 530200, China.
2. Guangxi University of Chinese Medicine Nanning 530200, China.
- Publication Type:English Abstract
- Keywords:
hypothalamic-pituitary-target gland axis;
kidney-Yang deficiency syndrome;
neuro-endocrine-immune system;
research progress;
traditional Chinese medicine
- MeSH:
Humans;
Yang Deficiency/physiopathology*;
Drugs, Chinese Herbal/therapeutic use*;
Medicine, Chinese Traditional;
Kidney Diseases/physiopathology*;
Neurosecretory Systems/physiopathology*;
Animals;
Kidney/physiopathology*;
Endocrine System/physiopathology*;
Immune System/physiopathology*
- From:
China Journal of Chinese Materia Medica
2025;50(15):4153-4165
- CountryChina
- Language:Chinese
-
Abstract:
Kidney-Yang deficiency syndrome is a common geriatric disease that underlies chronic conditions such as diabetic nephropathy, chronic kidney disease, and osteoporosis. As age progresses, the kidney-Yang deficiency syndrome showcases increasingly pronounced manifestations, emerging as a key factor in the comorbidities experienced by elderly patients and affecting their quality of life and overall health status. Traditional Chinese medicine(TCM) has been extensively utilized in the treatment of kidney-Yang deficiency syndrome, with Epimedii Folium, Cinnamomi Cortex, and Lycii Fructus widely used in clinical settings. Despite the complexity of the molecular mechanisms involved in treating kidney-Yang deficiency syndrome, the potential therapeutic value of TCM remains compelling. Delving into the mechanisms of TCM treatment of kidney-Yang deficiency syndrome by regulating the neuro-endocrine-immune system can provide a scientific basis for targeted treatments of this syndrome and lay a foundation for the modernization of TCM. The pathophysiology of kidney-Yang deficiency syndrome involves multiple systems, including the interaction of the neuro-endocrine-immune system, the decline in renal function, the intensification of oxidative stress responses, and energy metabolism disorders. Understanding these mechanisms and their interrelationships can help untangle the etiology of kidney-Yang deficiency syndrome, aiding clinicians in making more precise diagnoses and treatments. Furthermore, the research on the specific applications of TCM in research on these pathological mechanisms can enhance the international recognition and status of TCM, enabling it to exert a greater global influence.
