A new cephalotaxine-type alkaloid dimer from Cephalotaxus lanceolata.
10.19540/j.cnki.cjcmm.20250412.202
- Author:
Jia-Yang MA
1
;
Jing WANG
1
;
Sha CHEN
1
;
Chun-Lei YUAN
1
;
Jin-Yuan YANG
1
;
Da-Hong LI
1
;
Hui-Ming HUA
1
Author Information
1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University Shenyang 110016, China.
- Publication Type:Journal Article
- Keywords:
Cephalotaxus lanceolata;
alkaloid;
cytotoxic activity
- MeSH:
Cephalotaxus/chemistry*;
Humans;
Cell Line, Tumor;
Drugs, Chinese Herbal/pharmacology*;
Harringtonines/pharmacology*;
Molecular Structure;
Dimerization;
Alkaloids/isolation & purification*;
Magnetic Resonance Spectroscopy
- From:
China Journal of Chinese Materia Medica
2025;50(13):3729-3741
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents from Cephalotaxus lanceolata were isolated and purified by using multiple chromatographic techniques, including octadecylsilane(ODS), silica gel, Sephadex LH-20 column chromatography, and semi-preparative high-performance liquid chromatography(HPLC). A total of 17 compounds obtained were identified by using spectroscopic methods such as nuclear magnetic resonance(NMR), mass spectrometry(MS), and ultraviolet(UV) combined with literature data. Compound 1 was a new alkaloid dimer, named cephalancetine E. The known compounds were determined as cephalancetine A(2), 11-hydroxycephalotaxine(3), 4-hydroxycephalotaxine(4), cephalotaxine(5), epicephalotaxine(6), cephalotaxine β-N-oxide(7), acetylcephalotaxine(8), cephalotine A(9), cephalotine B(10), 11-hydroxycephalotaxine hemiketal(11), 3-deoxy-3,11-epoxy-cephalotaxine(12), cephalotaxinone(13), isocephalotaxinone(14), 2,11-epoxy-1,2-dihydro-8-oxo-cephalotaxine(15), cephalotaxamide(16), and drupacine(17), respectively. Compounds 11, 12, and 15 were isolated from the Cephalotaxus genus for the first time. The biological activity was tested for compounds 1-17. The results reveal that compound 17 displays potent inhibitory activities against three human cancer cell lines(HepG-2, MCF-7, and SH-SY5Y).
