Two new taraxerane triterpenoids from mastic.
10.19540/j.cnki.cjcmm.20250412.203
- Author:
Zhi-Qiang ZHAO
1
;
Xue-Rui AN
1
;
Tian-Zhi LI
2
;
Ting HE
3
;
Hao-Kun HOU
1
;
Wei LIU
1
;
Tao YUAN
3
Author Information
1. Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University Yining 835000, China.
2. Jiangxi Provincial Key Laboratory of Natural and Biomimetic Drugs Research, School of Health, Jiangxi Normal University Nanchang 330022, China.
3. Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University Yining 835000, China Jiangxi Provincial Key Laboratory of Natural and Biomimetic Drugs Research, School of Health, Jiangxi Normal University Nanchang 330022, China.
- Publication Type:Journal Article
- Keywords:
anti-inflammation;
chemical constituent;
mastic;
nortriterpenoid;
taraxerane
- MeSH:
Animals;
Mice;
Triterpenes/isolation & purification*;
Drugs, Chinese Herbal/isolation & purification*;
Mastic Resin/chemistry*;
Nitric Oxide;
Molecular Structure;
Macrophages/immunology*;
RAW 264.7 Cells
- From:
China Journal of Chinese Materia Medica
2025;50(13):3723-3743
- CountryChina
- Language:Chinese
-
Abstract:
Three taraxerane nortriterpenoids were isolated from mastic by using various modern chromatographic separation techniques. They were identified as(5R,8R,9R,10S,11S,12R,13S,17R,18R)-28-norlupa-11,12-epoxy-14-taraxerene-3,16-dione(1),(5R,8R,9R,10S,11S,12R,13S,17S,18S)-17-hydroxy-28-norlupa-11,12-epoxy-14-taraxerene-3-one(2), and(5R,8R,9R,10R,11S,12R,13R,14S,17S,18S)-14,17-epoxy-28-norlupa-11,12-oxidotaraxerone(3) through the high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), infrared(IR), ultraviolet(UV), nuclear magnetic resonance(NMR), and single-crystal X-ray diffraction techniques as well as comparison with literature data. Compounds 1-3 were C-28 nortriterpenoids and isolated from mastic for the first time, and compounds 1-2 were new ones. In the model for RAW264.7 cell anti-inflammation induced by lipopolysaccharide(LPS), compound 1 demonstrates an inhibitory effect on nitric oxide(NO) [IC_(50)=(13.38±0.68) μmol·L~(-1)], comparable to the activity of the positive control dexamethasone [IC_(50)=(14.59±1.49) μmol·L~(-1)]. Compounds 2 and 3 exhibit weaker inhibitory effects, with IC_(50) values of(24.17±2.56) and(22.25±2.84) μmol·L~(-1), respectively.
