Three new chalcone C-glycosides from Carthami Flos.
10.19540/j.cnki.cjcmm.20250412.201
- Author:
Jia-Xu BAO
1
;
Yong-Xiang WANG
1
;
Xian ZHANG
1
;
Ya-Zhu YANG
1
;
Yue LIN
1
;
Jiao-Jiao YIN
1
;
Yun-Fang ZHAO
2
;
Hui-Xia HUO
2
;
Peng-Fei TU
3
;
Jun LI
4
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
2. Modern Research Center for Traditional Chinese Medicine, Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China.
3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences,Peking University Beijing 100191, China.
4. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Modern Research Center for Traditional Chinese Medicine, Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
Carthami Flos;
cardioprotective activity;
chalcone C-glycoside;
chemical component
- MeSH:
Glycosides/pharmacology*;
Flowers/chemistry*;
Drugs, Chinese Herbal/pharmacology*;
Carthamus tinctorius/chemistry*;
Chalcones/pharmacology*;
Animals
- From:
China Journal of Chinese Materia Medica
2025;50(13):3715-3745
- CountryChina
- Language:Chinese
-
Abstract:
The chemical components of Carthami Flos were investigated by using macroporous resin, silica gel column chromatography, reversed-phase octadecylsilane(ODS) column chromatography, Sephadex LH-20, and semi-preparative high-performance liquid chromatography(HPLC). The planar structures of the compounds were established based on their physicochemical properties and ultraviolet-visible(UV-Vis), infrared(IR), high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), and nuclear magnetic resonance(NMR) spectroscopic technology. The absolute configurations were determined by comparing the calculated and experimental electronic circular dichroism(ECD). Six flavonoid C-glycosides were isolated from the 30% ethanol elution fraction of macroporous resin obtained from the 95% ethanol extract of Carthami Flos, and identified as saffloquinoside F(1), 5-hydroxysaffloneoside(2), iso-5-hydroxysaffloneoside(3), isosafflomin C(4), safflomin C(5), and vicenin 2(6). Among these, the compounds 1 to 3 were new chalcone C-glycosides. The compounds 1, 2, 4, and 5 could significantly increase the viability of H9c2 cardiomyocytes damaged by oxygen-glucose deprivation/reoxygenation(OGD/R) at a concentration of 50 μmol·L~(-1), showing their good cardioprotective activity.
