Research progress in pharmacological activities and pharmacokinetics of geniposidic acid.
10.19540/j.cnki.cjcmm.20250423.201
- Author:
Zi-Wei LI
1
;
Sheng-Lan QI
2
;
Qing-Guang ZHANG
2
;
Ling CHEN
3
;
Jing HU
3
;
Guang-Bo GE
2
;
Feng HUANG
4
Author Information
1. College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine Kunming 650500, China Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
3. Department of Nephropathy, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137, China.
4. College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine Kunming 650500, China.
- Publication Type:English Abstract
- Keywords:
anti-inflammatory and antioxidative effects;
geniposidic acid;
organ protection;
pharmacokinetics;
pharmacological activity
- MeSH:
Humans;
Drugs, Chinese Herbal/chemistry*;
Animals;
Iridoid Glucosides/chemistry*;
Plants, Medicinal/chemistry*;
Anti-Inflammatory Agents/pharmacology*
- From:
China Journal of Chinese Materia Medica
2025;50(13):3679-3691
- CountryChina
- Language:Chinese
-
Abstract:
Geniposidic acid(GA), a natural iridoid, exists in the roots, stems, leaves, flowers, bark, fruits, and seeds of medicinal plants of Rubiaceae, Eucommiaceae, and Plantaginaceae. Modern pharmacological studies have revealed that GA has multiple pharmacological activities, including organ-protective, anti-inflammatory, antioxidative, anti-osteoporosis, anti-neurodegenerative, and anti-cardiovascular effects. GA can enhance cell/organism defenses by upregulating key anti-inflammatory and antioxidant cytokines, while downregulating key node proteins in pro-inflammatory signaling pathways such as AhR and TLR4/MyD88, thereby exerting pharmacological effects such as organ protection. Pharmacokinetic investigations have suggested that after oral administration, GA can be distributed in multiple organs(kidney, liver, heart, spleen, lung, etc.). In addition, the pharmacokinetic behavior of GA could be significantly altered under disease conditions, as demonstrated by a marked increase in systematic exposure. This article comprehensively summarizes the reported pharmacological activities and mechanisms and systematically analyzes the pharmacokinetic characteristics and key parameters of GA, with the aim of providing a theoretical basis and scientific reference for the precise clinical application of GA-related Chinese patent medicines, as well as for the investigation and development of innovative drugs based on GA.
