Advances and future directions in discovery of active substances and target identification in traditional Chinese medicine: toward precision, efficiency, and intelligence.
10.19540/j.cnki.cjcmm.20250512.701
- Author:
Ye-Ting ZHOU
1
;
Lu ZHAO
1
;
Yi WANG
2
Author Information
1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China.
2. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China National Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta,Zhejiang University Jiashan 314100, China.
- Publication Type:English Abstract
- Keywords:
artificial intelligence;
key technologies;
new drug creation;
target discovery;
traditional Chinese medicine active substances
- MeSH:
Medicine, Chinese Traditional/methods*;
Drugs, Chinese Herbal/pharmacology*;
Humans;
Artificial Intelligence;
Drug Discovery/methods*;
Animals
- From:
China Journal of Chinese Materia Medica
2025;50(13):3657-3669
- CountryChina
- Language:Chinese
-
Abstract:
The study of active substances in traditional Chinese medicine(TCM) is the foundation of TCM pharmacology, TCM quality control, and new drug development, and it is also one of the most popular directions in TCM modernization research in recent years. Due to their diverse chemical compositions and complex component-effect relationships, Chinese medicines often require the comprehensive use of multidisciplinary technologies such as chemistry, biology, and information science to reveal their active substances and targets. In this paper, we review the innovative breakthroughs made in the past 30 years in the discovery strategies and technological means for the research of active substances in traditional Chinese medicine from the perspective of technological changes, and focus on the new direction of the research of active substances in traditional Chinese medicine under the paradigm shift of scientific research brought about by artificial intelligence, with the aim of promoting research in related fields to move in the direction of more accurate, efficient, and intelligent, and providing innovative ideas for the research of active substances in traditional Chinese medicine under the new situation.
