Rational use of drug and scientific regulation based on effect-toxicity bidirectional action of Gardeniae Fructus.
10.19540/j.cnki.cjcmm.20250126.401
- Author:
Shuang CUI
1
;
Jing-Zhuo TIAN
1
;
Ai-Hua LIANG
1
Author Information
1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:English Abstract
- Keywords:
Gardeniae Fructus;
effect-toxicity bidirectional action;
hepatoprotection;
hepatotoxicity;
mechanism of action
- MeSH:
Animals;
Humans;
Drugs, Chinese Herbal/pharmacology*;
Fruit/chemistry*;
Gardenia/chemistry*;
Medicine, Chinese Traditional;
Liver/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(13):3635-3644
- CountryChina
- Language:Chinese
-
Abstract:
Gardeniae Fructus, a traditional Chinese medicine, has significant pharmacological activities such as clearing heat and detoxifying, promoting bile secretion and protecting liver injury. It is widely used in clinical practice for treating conditions like fever-induced restlessness, damp-heat jaundice, dysuria with pain, and fire-toxin sores. Gardeniae Fructus has been included in "list of items that are both food and medicine", so it is also used as an ingredient in food and health products. However, recent toxicological studies have shown that Gardeniae Fructus has certain potential hepatotoxicity, and its improper use may pose a risk. Therefore, it is necessary to clarify the dual regulatory effects and their scientific connotations of Gardeniae Fructus on efficacy and toxicity. Based on the current progress in clinical, pharmacological and toxicological researches, this paper will discuss the characteristics and possible mechanisms of the dual effects of efficacy and toxicity of Gardeniae Fructus, and propose thoughts on the rational clinical use and scientific supervision of Gardeniae Fructus.
