A new perspective on quality control of traditional Chinese medicine based on characteristics of "physical phase structure".
10.19540/j.cnki.cjcmm.20250509.301
- Author:
Zhong-Huan QU
1
;
Yan-Jun YANG
1
;
Bing YANG
1
;
Ru-Yu SHI
2
;
Mao-Mao ZHU
3
;
Lu SUN
4
;
Xiao-Bin JIA
2
;
Liang FENG
4
Author Information
1. School of Traditional Chinese Pharmacy, Affiliated Jiangning Hospital of Chinese Medicine, China Pharmaceutical University Nanjing 211198, China Jiangsu Provincial Key Laboratory of Pediatric Traditional Chinese Medicine and Specialized Formulations, Jumpcan Pharmaceutical Co., Ltd. Taixing 225400, China.
2. School of Traditional Chinese Pharmacy, Affiliated Jiangning Hospital of Chinese Medicine, China Pharmaceutical University Nanjing 211198, China.
3. School of Traditional Chinese Pharmacy, Affiliated Jiangning Hospital of Chinese Medicine, China Pharmaceutical University Nanjing 211198, China Nanjing Institute of Product Quality Inspection Nanjing 210019, China.
4. School of Traditional Chinese Pharmacy, Affiliated Jiangning Hospital of Chinese Medicine, China Pharmaceutical University Nanjing 211198, China Nanjing Jiangning District Hospital of Chinese Medicine Nanjing 211100, China.
- Publication Type:English Abstract
- Keywords:
components;
physical phase structure;
quality control;
traditional Chinese medicine
- MeSH:
Quality Control;
Drugs, Chinese Herbal/standards*;
Medicine, Chinese Traditional/standards*;
Humans;
Drug Delivery Systems
- From:
China Journal of Chinese Materia Medica
2025;50(13):3579-3588
- CountryChina
- Language:Chinese
-
Abstract:
Quality control is a key link in the modernization process of traditional Chinese medicine(TCM). Studies have shown that the effects of active components in TCM depend on not only their chemical composition but also their suitable physical forms and states. The physical phase structures, such as micelles, vesicles, gels, and nanoparticles, can improve the solubility, delivery efficiency, and targeting precision of active components. These structures significantly enhance the pharmacological activity while reducing the toxicity and side effects, demonstrating functional activity surpassing that of active components and highlighting the key effects of "structures" on "functions" of active components. Taking the physical phase structure as a breakthrough point, this paper outlines the common types of TCM physical phase structures. Furthermore, this paper explores how to realize the quality upgrading of TCM through the precise regulation of physical phase structures based on the current applications and potential of TCM physical phase structures in processing to increase the efficacy and reduce the toxicity, compounding and decocting processes, drug delivery systems, and quality control, aiming to provide novel insights for the future quality control of TCM.
