Study on chemical constituents of Rhododendri Mollis Flos.
10.19540/j.cnki.cjcmm.20250509.201
- Author:
Peng-Yu GUO
1
;
Yang SONG
1
;
Hai-Qiang WANG
1
;
Shi-Shan YU
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Rhododendri Mollis Flos;
Rhododendron;
Rhododendron molle;
analgesic activity;
chemical constituent
- MeSH:
Drugs, Chinese Herbal/isolation & purification*;
Rhododendron/chemistry*;
Animals;
Flowers/chemistry*;
Mice;
Male;
Analgesics/isolation & purification*;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2025;50(14):3938-3943
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the chemical constituents of Rhododendri Mollis Flos. The n-butanol fraction of 95% ethanol extract of Rhododendri Mollis Flos was separated and purified using chromatographic techniques, including normal-phase silica gel, ODS, and Sephadex LH-20 column chromatography. The structures of the isolated compounds were identified by spectroscopic techniques. Seven compounds were isolated and identified as rhodomollein LXⅦ(1), rhodomollein X(2), nivalenol(3),(3S,6S)-cis-linalool-3,7-oxide-β-D-glucopyranoside(4), thymidine(5), cyclo(Ala-Tyr)(6), and(S)-5-hydroxypyrrolidin-2-one(7). Among them, compound 1 was identified as a new compound, and compound 3 was isolated from this plant for the first time. The analgesic activity of compound 1 was evaluated using the acetic acid-induced writhing test. At a dose of 5.0 mg·kg~(-1), compound 1 showed a 75.4% inhibition rate in the writhing test, indicating significant analgesic activity.
