A new nor-clerodane diterpenoid from Croton lauioides.
10.19540/j.cnki.cjcmm.20250222.202
- Author:
Hao-Xin WANG
1
;
Wen-Hao DU
1
;
Hong-Xi XIE
1
;
Lin CHEN
1
;
Jun-Jie HAO
2
;
Zhi-Yong JIANG
1
Author Information
1. Yunnan Key Laboratory of Dai and Yi Medicine, College of Ethnomedicine, Yunnan University of Chinese Medicine Kunming 650500, China.
2. College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine Kunming 650500, China.
- Publication Type:Journal Article
- Keywords:
Croton lauioides;
clerodane diterpenoid;
lauioidine
- MeSH:
Croton/chemistry*;
Diterpenes, Clerodane/isolation & purification*;
Molecular Structure;
Drugs, Chinese Herbal/isolation & purification*;
Magnetic Resonance Spectroscopy;
Chromatography, High Pressure Liquid
- From:
China Journal of Chinese Materia Medica
2025;50(11):3049-3053
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of the chloroform extract of the 90% methanol extract obtained from the dried branches and leaves of Croton lauioides were investigated. By using silica gel column chromatography, C_(18 )column chromatography, MCI column chromatography, and semi-preparative high-performance liquid chromatography(HPLC), six compounds were isolated. Their structures were identified as lauioidine(1), 2α-methoxy-8α-hydroxy-6-oxogermacra-1(10),7(11)-dien-8,12-olide(2), myrrhanolide B(3), gossweilone(4), 6β,7β-epox-4α-hydroxyguaian-10-ene(5), and 4(15)-eudesmane-1β,5α-diol(6) by analyzing the HR-ESI-MS, IR, ECD, 1D NMR and 2D NMR data, as well as their physicochemical properties. All compounds were isolated from C. lauioides for the first time, among which compound 1 is a new nor-clerodane diterpenoid.
