A new amide alkaloid from Cannabis Fructus.
10.19540/j.cnki.cjcmm.20250222.201
- Author:
Rui-Wen XU
1
;
Yong-Zhuo ZHAO
1
;
Yu-Guo MA
1
;
Hui LIU
1
;
Yan-Jun SUN
2
;
Wei-Sheng FENG
2
;
Hui CHEN
2
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046, China.
2. School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046, China Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-construction by Henan Province & Ministry of Education Zhengzhou 450046, China.
- Publication Type:Journal Article
- Keywords:
Cannabis Fructus;
amide alkaloid;
chemical constituent;
α-glucosidase inhibitory activity
- MeSH:
Cannabis/chemistry*;
Alkaloids/pharmacology*;
Amides/isolation & purification*;
Drugs, Chinese Herbal/isolation & purification*;
Fruit/chemistry*;
Molecular Structure;
alpha-Glucosidases/chemistry*;
Chromatography, High Pressure Liquid
- From:
China Journal of Chinese Materia Medica
2025;50(11):3043-3048
- CountryChina
- Language:Chinese
-
Abstract:
Eight amide alkaloids(1-8) were isolated from the 70% ethanol extract of Cannabis Fructus using silica gel column chromatography, MCI column chromatography, and semi-preparative high-performance liquid chromatography(HPLC). Their structures were identified as hempspiramide A(1), N-[(4-hydroxyphenyl)ethyl]formamide(2), N-acetyltyramide(3), N-trans-p-coumaroyltyramine(4), N-trans-caffeoyltyramine(5), N-trans-feruloyltyramine(6), N-cis-p-coumaroyltyramine(7), N-cis-feruloyltyramine(8) by using spectroscopic methods such as NMR and MS. Among these compounds, compound 1 was a new amide alkaloid, while compounds 2 and 3 were isolated from Cannabis Fructus for the first time. Some of the isolates were assayed for their α-glucosidase inhibitory activity. Compounds 5-7 displayed significant inhibitory activity against α-glucosidase with IC_(50) values ranging from 1.07 to 4.63 μmol·L~(-1).
