Research progress in pharmacological effects of puerarin.
10.19540/j.cnki.cjcmm.20250311.601
- Author:
Xiao-Wei MENG
1
;
Feng-Mei GUO
1
;
Qian-Qian WANG
1
;
Jia-Rong LI
1
;
Ni ZHANG
1
;
Fei QU
2
;
Rong-Hua LIU
1
;
Wei-Feng ZHU
2
Author Information
1. Jiangxi University of Chinese Medicine Nanchang 330004,China Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine,Jiangxi University of Chinese Medicine Nanchang 330004,China.
2. Jiangxi University of Chinese Medicine Nanchang 330004,China.
- Publication Type:English Abstract
- Keywords:
Puerariae Lobate Radix;
mechanism;
pharmacological effect;
puerarin;
research progress
- MeSH:
Isoflavones/chemistry*;
Humans;
Animals;
Drugs, Chinese Herbal/chemistry*;
Pueraria/chemistry*
- From:
China Journal of Chinese Materia Medica
2025;50(11):2954-2968
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM), a treasure of the Chinese nation, contains abundant chemical components and demonstrates unique pharmacological activities, showing important values in clinical applications. With profound connotations and broad application prospects, TCM urgently needs us to further explore and conduct systematic research. Puerarin is a small-molecule natural isoflavonoid carbon glycoside extracted from plants of Pueraria. It is also the main active ingredient of Puerariae Lobata Radix, a Chinese herbal medicine with both medicinal and edible values. Puerarin has a variety of pharmacological effects such as blood pressure-lowering, anti-atherosclerosis, anti-ischemia-reperfusion injury, antithrombotic, anti-tumor, anti-inflammatory, liver-protecting, nerve cell-protecting, and intestinal microbiota-regulating effects. It is also an active ingredient that has been widely studied. This article comprehensively reviews the research progress in the pharmacological effects and molecular mechanisms of puerarin over the years, aiming to provide references and theoretical support for the in-depth research and development as well as clinical application of puerarin.
